摘要
目的:观察水飞蓟宾胶囊联合甘草酸二铵治疗病毒性肝炎患者的效果。方法:回顾性分析2020年5月至2022年11月该院收治的114例病毒性肝炎患者的临床资料,根据治疗方法不同将其分为对照组和观察组各57例。对照组采用甘草酸二铵治疗,观察组在对照组基础上联合水飞蓟宾胶囊治疗。比较两组临床疗效,治疗前后肝功能指标[丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)]水平、氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)]水平、免疫因子[白细胞介素-4(IL-4)、γ干扰素(IFN-γ)]水平,以及不良反应发生率。结果:观察组治疗总有效率为91.23%(52/57),高于对照组的77.19%(44/57),差异有统计学意义(P<0.05)。治疗后,两组ALT、AST、TBIL水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组SOD水平均高于治疗前,且观察组高于对照组,两组MDA水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组IL-4水平均低于治疗前,且观察组低于对照组,两组IFN-γ水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:水飞蓟宾胶囊联合甘草酸二铵治疗病毒性肝炎患者可提高治疗总有效率,改善氧化应激指标和免疫因子水平,降低肝功能指标水平,效果优于单纯甘草酸二铵治疗。
Objective:To observe effects of Silibinin capsules combined with Diammonium glycyrrhizinate in treatment of patients with viral hepatitis.Methods:The clinical data of 114 patients with viral hepatitis admitted to this hospital from May 2020 to November 2022 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,57 cases in each group.The control group was treated with Diammonium glycyrrhizinate,while the observation group was treated with Silibinin capsules on the basis of that of the control group.The clinical efficacy,the liver function indexes[alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL)]levels,the oxidative stress indexes[malondialdehyde(MDA),superoxide dismutase(SOD)]levels,the immune factors[interleukin-4(IL-4),interferon-γ(IFN-γ)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 91.23%(52/57),which was higher than 77.19%(44/57)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of ALT,AST and TBIL in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The SOD levels of the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;the MDA levels of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).The levels of IL-4 in the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;the levels of IFN-γin the two groups were higher than those before the treatment,and that in the observation group was higher than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Silibinin capsules combined with Diammonium glycyrrhizinate in the treatment of the patients with viral hepatitis can improve the total effective rate of treatment,improve the levels of oxidative stress indexes and immune factors,and reduce the levels of liver function indexes.Moreover,it is superior to single Diammonium glycyrrhizinate treatment.
作者
徐苛
钟思鹏
张国胜
XU Ke;ZHONG Sipeng;Zhang Guosheng(Department of Infectious Diseases of the Fifth People’s Hospital of Xinyang City,Xinyang 464000 Henan,China)
出处
《中国民康医学》
2024年第12期22-25,共4页
Medical Journal of Chinese People’s Health
关键词
病毒性肝炎
水飞蓟宾胶囊
甘草酸二铵
肝功能
氧化应激
免疫因子
不良反应
Viral hepatitis
Silibinin capsules
Diammonium glycyrrhizinate
Liver function
Oxidative stress
Immune factor
Adverse reaction
