摘要
溃疡性结肠炎(UC)是一种非特定性的炎性肠道问题,其主要症状包括腹痛、腹泻和黏液血便,有易复发,较难治的特点。该疾病的发病机制尚未完全明确,现代医学治疗手段效果欠佳,加之多年来,UC发病率呈逐年上升的趋势,故临床迫切需要寻找新的治疗方法。中医药防治此类病证由来已久,仲景曾在《伤寒论》原文中多次论及下利、泄利与久痢、肠风、脏毒等与UC相类似的症状,论述了相应病机与治法,并提出有效的治疗方剂,为后世运用经方辨治UC奠定了基础。近年来,研究发现中医药对防治UC具有独特的优势,不仅能够有效缓解UC患者的症状,还能在很大程度上改善患者的生活质量。研究还发现,无论是从网络药理学、临床观察亦是动物实验,半夏泻心汤类方作为一种中药复方,在治疗UC方面取得了显著的疗效。经过大量的实验探索,研究发现半夏泻心汤类方在治疗UC的原理上与细胞炎症因子、肠道微生物、免疫反应、相关的信号传导途径和细胞焦亡等因素有紧密的关联。本文将会对半夏泻心汤类方在治疗UC中的作用原理做一个全面的概括,包括其理论根源、药物组成和作用机制等各个方面的研究,旨在给临床实践提供更加稳固的理论支持。
The persistent,difficult-to-treat,and recurrent abdominal pain,diarrhea,and mucinous bloody stools that characterize ulcerative colitis(UC)are indicative of an inflammatory bowel disorder.The cause of the sickness remains uncertain,and the outcome of modern medical treatment is not encouraging.The incidence of UC has been steadily increasing over time,making it essential to discover novel treatments in clinical practice.For centuries,traditional Chinese medicine(TCM)has been a successful method for preventing and curing this malady.In the original text of Shanghanlun,ZHANG Zhongjing repeatedly discussed symptoms similar to UC,such as diarrhea,chronic dysentery,intestinal wind,and visceral toxins.The effective formulas proposed in Shanghanlun have laid the groundwork for the later use of TCM for treatment of UC.Research in recent times has revealed the distinct benefits of TCM in both relieving the symptoms and improving the quality of life of UC patients.Banxia Xiexintang,a compound of this type,has been found to be effective in network pharmacology,molecular docking,clinical observation,and animal experiments,and its therapeutic effects have been considerable in the treatment of UC.Extensive experiments have revealed a strong correlation between the effectiveness of Banxia Xiexintang in treating UC and factors such as inflammatory cytokines,intestinal microbiota,immune responses,related signaling pathways,and pyroptosis.This article presents a comprehensive examination of Banxia Xiexintang for treatment of UC,encompassing its theoretical basis,drug composition,and mechanism of action.This paper is expected to provide more theoretical support for clinical application of Banxia Xiexintang.
作者
张亚粉
左振魁
刘天瑞
ZHANG Yafen;ZUO Zhenkui;LIU Tianrui(Henan University of Chinese Medicine,Zhengzhou 450046,China;Henan Province Hospital of TCM/The Second Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450002,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2024年第13期279-288,共10页
Chinese Journal of Experimental Traditional Medical Formulae
基金
河南省中医药拔尖人才培养项目(2022ZYBJ11)
河南省中医药科学研究专项(2019ZY2022)
河南省研究生教育改革与质量工程项目(YJS2021AL059)。
关键词
伤寒论
半夏泻心汤
溃疡性结肠炎
研究进展
机制
Shanghanlun
Banxia Xiexintang
ulcerative colitis
research progress
mechanism
