摘要
以DBU修饰的M/MCM-41为催化剂,固定床为反应器,采用2,3,6-三氯吡啶为原料,H2氛围下,还原反应合成2,3-二氯吡啶。系统考查了金属种类、金属含量、反应温度、反应压力以及空速的影响,筛选出最优的反应条件:4%的Pd/MCM-41-DBU为催化剂,温度为80℃,压力为0.6 MPa,空速为0.4 h-1,2,3,6-三氯吡啶∶甲苯∶三乙胺=1∶6∶1.2(摩尔比),此条件下2,3-二氯吡啶的收率最高,达94.1%。该工艺操作简单,安全性高,收率高,适合工业化生产。
The 2,3-dichloropyridine was synthesized by using the 2,3,6-trichloropyridine as raw material in fixed bed reactor.The influence of metal type,metal content,residence temperature,pressure and airspeed were systematically investigated,and suitable reaction conditions were selected.The optimal conditions for diazotization were as follows:metal type was Pd,metal content was 4%,the temperature was 80℃,the pressure was 0.6 MPa and the airspeed was 0.4 h-1,the yield of 2,3-dichloropyridine was the highest,at 94.1%,respectively.The process realizes the continuous synthesis of 2,3-dichloropyridine has high safety and high yield,and is suitable for industrial production.
作者
刘敏
张明祥
周淳
赵伟杰
杜承建
LIU Min;ZHANG Ming-xiang;ZHOU Chun;ZHAO Wei-jie;DU Cheng-jian(Anhui Costar Biological Chemical Co.Ltd.,Maanshan 243100,China)
出处
《安徽化工》
CAS
2024年第3期76-80,共5页
Anhui Chemical Industry
