摘要
由于具有抗菌活性,纳米粒子(NPs)和抗菌肽(AMPs)相结合可以用来杀死耐药(MDR)病原体。纳米银(AgNPs)具有广谱高效的抗菌性能、多种细菌灭活机制,并能对抗菌肽共轭银纳米粒子(AMP-AgNPs)表面进行共轭微调,使得AMP-AgNPs具有更高的生物安全性。文章综述了AMP-AgNPs偶联物的最新研究进展,讨论了AMP-AgNPs偶联物的合成方式、抗菌活性、作用机制、溶血毒性以及其在医疗和食品领域的应用,并对其未来发展方向进行了展望。
Due to antimicrobial activity,nanoparticles(NPs)in combination with antimicrobial peptides(AMPs)can be used to kill drug-resistant(MDR)pathogens.Nanosilver(AgNPs)has broad-spectrum and efficient antimicrobial properties,multiple bacterial inactivation mechanisms,and the ability to fine-tune the conjugation on the surface of antimicrobial peptide-conjugated silver nanoparticles(AMP-AgNPs),which results in higher biosafety of AMP-AgNPs.The review summarized the latest research progress of AMP-AgNPs conjugates and discussed the synthesis method,antibacterial activity,mechanism of action,hemolytic toxicity of AMP-AgNPs conjugates,as well as their applications in medical and food fields.The future development direction of AMP-AgNPs conjugates was also prospected.
作者
谢闰生
李培骏
蒋羽秋
曹兴业
李海云
苏东林
XIE Runsheng;LI Peijun;JIANG Yuqiu;CAO Xingye;LI Haiyun;SU Donglin(College of Chemistry&Bioengineering,Guilin University of Technology,Guilin,Guangxi 541004,China;Provincial Key Laboratory for Utilization and Conservation of Food and Medicinal Resources in Northern Guangdong,Shaoguan University,Shaoguan,Guangdong 512005,China;College of Food Science&Technology,Shaoguan University,Shaoguan,Guangdong 512005,China;Hunan Agricultural Product Processing Institute,Changsha,Hunan 410125,China)
出处
《食品与机械》
CSCD
北大核心
2024年第5期219-226,共8页
Food and Machinery
基金
国家重点研发计划项目(编号:2022YFD2100804)
韶关市支持科研工作者项目(编号:230324098034896)
韶关学院人才引进项目(编号:142-9900064701)。
关键词
细菌感染
抗菌肽
偶联物
生物安全性
医疗
食品
bacterial infection
antimicrobial peptides
coupling
biosafety
medical
food
