摘要
目的:比较与分析甘草酸类制剂与核苷(酸)类似物联用对慢性乙型肝炎(chronic hepatitis B,CHB)患者的临床疗效与安全性。方法:在Pubmed、Embase和中国知网、万方医学网、维普等数据库中,检索建库至2023年10月甘草酸类制剂与核苷(酸)类似物联用对CHB患者临床疗效与安全性的随机对照试验(randomized controlled trial)研究,采用Stata1和Revman等软件进行甘草酸类制剂与核苷(酸)类似物联用对CHB患者的临床疗效与安全性的网状Meta分析。结果:筛选后共纳入文献42篇,共涉及病例3991例;网状Meta分析结果显示,甘草酸类制剂与核苷(酸)类似物联用对CHB患者在丙氨酸转氨酶、天冬氨酸转氨酶、总胆红素等指标上的疗效均优于单用核苷(酸)类似物(P<0.05);在用药安全性方面,甘草酸类制剂与核苷(酸)类似物联用和单用核苷(酸)类似物的药物不良反应发生率经比较其差异无统计学意义(P>0.05)。结论:甘草酸类制剂与核苷(酸)类似物联用对CHB患者的疗效较为肯定,安全性也较高。
Objective:To compare and analyze the clinical efficacy and safety of glycyrrhizic acid preparations combined with nucleoside(nucleotide)analogs in patients with chronic hepatitis B(CHB).Methods:Randomized controlled trials on the clinical efficacy and safety of glycyrrhizic acid preparations combined with nucleoside(nucleotide)analogs in patients with CHB were searched from the database establishment date to October 2023 in the databases such as Pubmed,Embase,CNKI,Wanfang Medical Network,and VIP.The Stata1 and Revman software were used to perform a network meta-analysis of the clinical efficacy and safety of glycyrrhizic acid preparations combined with nucleoside(nucleotide)analogs in patients with CHB.Results:After screening,42 articles were included,involving a total of 3991 cases.The results of the network meta-analysis showed that the efficacy of glycyrrhizic acid preparations combined with nucleoside(nucleotide)analogs in CHB patients was superior to nucleoside(nucleotide)analogs alone in terms of the indexes such as ALT,AST and total bilirubin(P<0.05).In terms of medication safety,the difference of incidence of adverse drug reactions between glycyrrhizic acid preparations combined with nucleoside(nucleotide)analogs and nucleoside(nucleotide)analogs alone was not statistically significant(P>0.05).Conclusion:The efficacy of glycyrrhizic acid preparations combined with nucleoside(nucleotide)analogs is more definite in CHB patients with a high safety.
作者
范小冬
张杰
谢星星
罗宗伟
FAN Xiao-dong;ZHANG Jie;XIE Xing-xing;LUO Zong-wei(Xichong People's Hospital,Nanchong Sichuan 637200,China;Nanbu People's Hospital,Nanchong Sichuan 637300,China;Ya'an People's Hospital,Ya'an Sichuan 625000,China)
出处
《抗感染药学》
2024年第4期370-377,共8页
Anti-infection Pharmacy
基金
四川省医院协会青年药师科研专项资金项目(编号:22045)
四川省医学会(恒瑞)科研基金专项科研课题(编号:2021HR26)。
