摘要
目的探究在对糖尿病患者中使用二甲双胍联合西格列汀及吡格列酮的治疗效果。方法选取2023年5—12月龙岩市永定区医院内分泌科收治的300例糖尿病患者为研究对象,按照治疗方法不同分为两组,每组150例。观察组开展二甲双胍联合西格列汀治疗,对照组开展二甲双胍联合吡格列酮治疗。对比两组血糖、血脂改善情况。结果治疗后,两组糖化血红蛋白、餐后2 h血糖、空腹血糖均下降,且观察组低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组甘油三酯、总胆固醇以及低密度脂蛋白胆固醇水平低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组胰岛β细胞功能指数高于对照组,胰岛素抵抗指数低于对照组,差异有统计学意义(P均<0.05)。结论在对糖尿病患者治疗时,采用二甲双胍、西格列汀联合用药,能够更好地改善患者血糖、血脂水平,并提升患者胰岛功能。
Objective To explore the effect of following metformin combined with sitagliptin and pioglitazone in the treatment of diabetic patients.Methods A total of 300 diabetic patients admitted to the Department of Endocrinology,Yongding District Hospital,Longyan City from May to December 2023 were selected as the research objects,and they were divided into two groups with 150 cases in each group according to different treatment methods.The observation group was treated with metformin combined with sitagliptin,and the control group was treated with metformin com-bined with pioglitazone.The improvement of blood glucose and blood lipids between the two groups was compared.Results After treatment,glycosylated hemoglobin A1c,2-hour postprandial blood glucose and fasting blood glucose decreased in the two groups,and the observation group was lower than the control group,and the differences were sta-tistically significant(all P<0.05).After treatment,the levels of triacylglycerol,total cholesterol and low density lipopro-tein cholesterol in the observation group were lower than those in the control group,the differences were statistically significant(all P<0.05).After treatment,the homeostasis model assessment ofβcells function in the observation group was higher than that of the control group,and the homeostasis model assessment of insulin resistance was lower than that of the control group,and the difference was statistically significant(both P<0.05).Conclusion In the treatment of diabetic patients,the combination of metformin and sitagliptin can better improve the blood glucose and lipid levels of patients and improve the function of pancreatic islets.
作者
张玉武
张丽欣
赖小金
ZHANG Yuwu;ZHANG Lixin;LAI Xiaojin(Department of Endocrinology,Longyan Yongding District Hospital,Longyan,Fujian Province,364100 China;Department of Personnel,Longyan Yongding District Hospital,Longyan,Fujian Province,364100 China;Department of Third Internal Medicine,Longyan Yongding District Hospital,Longyan,Fujian Province,364100 China)
出处
《糖尿病新世界》
2024年第7期86-89,共4页
Diabetes New World Magazine
关键词
二甲双胍
西格列汀
吡格列酮
糖尿病
Metformin
Sitagliptin
Pioglitazone
Diabetes mellitus
