摘要
目的 研究雌二醇(estradiol,E_(2))与低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)对绝经后动脉粥样硬化性缺血性脑卒中(ischemic stroke,IS)的临床意义。方法 选取2022年3月至2023年3月于湖州市第一人民医院就诊的110例绝经后动脉粥样硬化性IS患者纳入研究组、110例绝经后非动脉粥样硬化性IS患者纳入疾病对照组及绝经后健康女性110例纳入健康组,比较各组受试者的血清E_(2)、LDL-C水平差异。分析血清E_(2)、LDL-C水平与绝经后动脉粥样硬化性IS患者疾病程度的关系,明确影响绝经后动脉粥样硬化性IS患者疾病程度的危险因素。结果 三组受试者的血清E_(2)、LDL-C水平比较差异均有统计学意义(P<0.05),其中健康组E_(2)水平>疾病对照组>研究组,健康组LDL-C水平<疾病对照组<研究组。中重型组患者的血清E_(2)显著低于轻型组,LDL-C显著高于轻型组(P<0.05)。血清E_(2)与美国国立卫生研究院卒中量表(National Institutes of Health stroke scale,NIHSS)评分、LDL-C均呈负相关(P<0.05),LDL-C与NIHSS评分呈正相关(P<0.05)。Logistic回归分析结果显示,年龄、NIHSS评分、颈动脉狭窄程度、C反应蛋白、脂蛋白相关磷脂酶A2、E_(2)、LDL-C均是影响绝经后动脉粥样硬化性IS疾病程度的危险因素(P<0.05)。结论 绝经后动脉粥样硬化性IS患者的血清E_(2)水平降低,LDL-C水平升高,与患者疾病严重程度有关,是导致患者疾病加重的危险因素。
Objective To study the clinical significance of estradiol(E_(2)) and low-density lipoprotein cholesterol(LDL-C) in postmenopausal atherosclerotic ischemic stroke(IS).Methods A total of 110 postmenopausal patients with atherosclerotic IS who were treated in the First People's Hospital of Huzhou from March 2022 to March 2023 were included in study group,110 postmenopausal patients with non-atherosclerotic IS were included in disease control group,and 110 healthy postmenopausal women were included in health group.The serum E_(2) and LDL-C were compared among all groups.The relationship between serum E_(2) and LDL-C levels and the degree of disease in postmenopausal patients with atherosclerotic IS was analyzed.To explore the risk factors that influence the degree of disease in postmenopausal patients with atherosclerotic IS.Results There were significant differences in serum E_(2) and LDL-C levels among three groups(P<0.05),including E_(2) level in healthy group >disease control group > study group,and LDL-C level in healthy group < disease control group < study group.Serum E_(2) in moderate and severe group was significantly lower than that in light group,LDL-C was significantly higher than that in light group(P<0.05).Serum E_(2) was negatively correlated with National Institutes of Health stroke scale(NIHSS) score and LDL-C(P<0.05),and LDL-C was positively correlated with NIHSS score(P<0.05).Logistic regression analysis showed that age,NIHSS score,degree of carotid artery stenosis,C-reactive protein,lipoprotein-associated phospholipase A2,E_(2) and LDL-C were risk factors for the degree of postmenopausal atherosclerotic IS disease(P<0.05).Conclusion The decrease of serum E2 level and the increase of LDL-C level in postmenopausal patients with atherosclerotic IS are related to the severity of patient's disease and are risk factors leading to the exacerbation of patient's disease.
作者
车旭霞
张敏
张丹
CHE Xuxia;ZHANG Min;ZHANG Dan(Department of Neurology,the First People’s Hospital of Huzhou,Huzhou 313000,Zhejiang,China)
出处
《中国现代医生》
2024年第16期74-78,89,共6页
China Modern Doctor
