摘要
目的探究肝脾硬度联合门静脉宽度与酒精性肝硬化食管胃底静脉曲张严重程度的关系。方法选取2020年1月至2022年12月赣州市第五人民医院收治的240例酒精性肝硬化患者作为研究对象,根据食管胃底静脉曲张的程度分为A组(60例,轻度食管胃底静脉曲张)、B组(60例,中度食管胃底静脉曲张)、C组(60例,重度食管胃底静脉曲张)与D组(60例,无食管胃底静脉曲张)。检测及比较四组的肝脏硬度值、脾脏硬度值及门静脉宽度检测值及异常率、门静脉及脾静脉血流量和血流速,采用Spearman秩相关分析肝脏硬度值、脾脏硬度值、门静脉宽度、门静脉及脾静脉血流量和血流速与酒精性肝硬化食管胃底静脉曲张严重程度的关系。结果A组、B组及C组的肝脏硬度值、脾脏硬度值及门静脉宽度检测值、脾静脉血流量和血流速高于D组,门静脉血流量和血流速低于D组,A组、B组及C组的肝脏硬度值、脾脏硬度值及门静脉宽度检测值、脾静脉血流量和血流速比较,差异有统计学意义(P<0.05),A组、B组及C组的肝脏硬度值、脾脏硬度值及门静脉宽度异常率高于D组,C组高于A组及B组,B组则高于A组,差异有统计学意义(P<0.008)。A组、B组及C组的门静脉血流量和血流速比较,差异无统计学意义(P>0.05),Spearman秩相关性分析显示,肝脏硬度值、脾脏硬度值、门静脉宽度、脾静脉血流量和血流速与酒精性肝硬化食管胃底静脉曲张严重程度呈正相关(r_(s)=0.836,0.819,0.793,0.761,0.802,P<0.05)。结论肝脾硬度与门静脉宽度在酒精性肝硬化食管胃底静脉曲张患者中呈现显著异常的状态,且与疾病的严重程度有密切的关系。
Objective To investigate the correlation between liver and spleen hardness combined with portal vein width and esophageal gastric varices severity of patients with alcoholic cirrhosis.Methods A total of 240 patients with alcoholic cirrhosis in the Fifth People's Hospital of Ganzhou City from January 2020 to December 2022 were selected as the study subjects,they were divided into group A(60 cases,mild esophageal gastric varices),group B(60 cases,moderate esophageal gastric varices),group C(60 cases,severe esophageal gastric varices)and group D(60 cases,without esophageal gastric varices)according to the differences of esophageal gastric varices severity.Then the detection value and abnormal rates of liver hardness value,spleen hardness value and portal vein width,blood flow volume and flow velocity of portal vein and splenic vein of four groups were detected and compared,then the correlation between liver hardness value,spleen hardness value and portal vein width,blood flow volume and flow velocity of portal vein and splenic vein and severity of esophageal gastric varices caused by alcoholic cirrhosis were analyzed with Spearman rank correlation analysis.Results The detection value of liver hardness value,spleen hardness value and portal vein width,blood flow volume and flow velocity of splenic vein of group A,group B and group C were higher than those of group D,the blood flow volume and flow velocity of portal vein were lower than those of group D,the detection value of liver hardness value,spleen hardness value and portal vein width,blood flow volume and flow velocity of splenic vein of group A,group B and group C were compared,the differences were statistically significant(P<0.05).The abnormal rates of liver hardness value,spleen hardness value and portal vein width of group A,group B and group C were higher than those of group D,the rates of group C were were significantly higher than those of group A and group B,the rates of group B were significantly higher than those of group A,the differences were statistically significant(P<0.008).The blood flow volume and flow velocity of portal vein of group A,group B and group C were compared,the differences were not statistically significant(P>0.05).The Spearman rank correlation analysis showed the abnormal rates of liver hardness value,spleen hardness value and portal vein width,blood flow volume and flow velocity of splenic vein were positively correlated with severity of esophageal gastric varices caused by alcoholic cirrhosis,the blood flow volume and flow velocity of portal vein were negatively correlated with severity of esophageal gastric varices caused by alcoholic cirrhosis(r_(s)=0.836,0.819,0.793,0.761,0.802,P<0.05).Conclusion The liver and spleen hardness and portal vein width in the patients with esophageal gastric varices caused by alcoholic cirrhosis are significant,and they have close relationship with the severity esophageal gastric varices caused by alcoholic cirrhosis.
作者
郭声
罗颖敏
曾艺军
包龙远
魏应凤
GUO Sheng;LUO Yingmin;ZENG Yijun;BAO Longyuan;WEI Yingfeng(Department of Hepatopathy,the Fifth People's Hospital of Ganzhou City,Jiangxi Province,Ganzhou341000,China)
出处
《中国当代医药》
CAS
2024年第16期30-33,41,共5页
China Modern Medicine
基金
江西省卫生健康委科技计划项目(20204688)。
关键词
肝脾硬度
门静脉宽度
酒精性肝硬化
食管胃底静脉曲张
严重程度
Liver hardness
Spleen hardness
Portal vein width
Alcoholic cirrhosis
Esophageal gastric varices
Severity
