摘要
目的 分析瘦型非酒精性脂肪性肝病(NAFLD)脾虚证患者临床实验室指标的特点,及其与痩型NAFLD脾虚证之间的相关性。方法 选择2019年12月至2021年12月在上海市普陀区中心医院消化内科门诊、住院部及上海市白玉社区卫生服务中心就诊的瘦型NAFLD患者336例,根据脾虚证患者报告结局指标量表将痩型NAFLD患者分为脾虚组(195例)和非脾虚组(141例)。收集患者基本信息,肝肾功能、血脂、血常规,以及肿瘤指标,并对常见的临床实验室指标进行比较分析,并采用SIMCA 14.1软件对这些指标进行相关性分析。结果 脾虚证组平均红细胞血红蛋白浓度低于非脾虚证组(P<0.05)。脾虚证组碱性磷酸酶、丙氨酸转氨酶、天冬氨酸转氨酶、空腹血糖、甘油三酯高于非脾虚证组,肌酐、尿酸低于非脾虚证组(P<0.01)。两组肿瘤指标比较,差异无统计学意义(P>0.05)。主成分分析后发现,两组人群区分度不明显,X/Y Overview Plot PCA分析、Loading Scatter Plot均提示血红蛋白、红细胞压积、平均血红蛋白含量对判断瘦型NAFLD患者脾虚证意义最大。结论 虽然红细胞系统参数与脾虚证具有高度相关性,但常规的实验室检查可能无法精准地诊断和鉴别痩型NAFLD脾虚证患者。
Objective To analyze the characteristics of clinical laboratory indicators in patients with spleen deficiency syndrome of lean nonalcoholic fatty liver disease(NAFLD),and to explore correlation between clinical laboratory indicators and spleen deficiency syndrome of lean NAFLD.Methods A total of 336 patients with lean NAFLD were selected from the Department of Gastroenterology Outpatient and Inpatient of Shanghai Putuo District Central Hospital and Shanghai Baiyu Community Health Service Center from December 2019 to December 2021.According to the spleen deficiency syndrome patient report outcome index scale,the NAFLD patients were divided into spleen deficiency syndrome group(195 cases) and non-spleen deficiency syndrome group(141 cases).Basic information,liver and kidney function,blood lipids,routine blood,and tumor indicators of patients were collected,and common clinical laboratory indicators of these patients were compared and analyzed,and correlation analysis of these indicators was performed using SIMCA 14.1 software.Results The mean corpuscular hemoglobin concentration in spleen deficiency syndrome group was lower than that in non-spleen deficiency syndrome group(P <0.05).The levels of alkaline phosphatase,alanine transaminase,aspartate transamin ase,fasting blood glucose,and triglyceride in the spleen deficiency syndrome group were higher than those in the non-spleen deficiency syndrome group,and the levels of creatinine and uric acid were lower than those in the non-spleen deficiency syndrome group(P<0.01).There was no significant difference in tumor indexes between the two groups(P >0.05).After principal component analysis,it was found that the difference between the two groups was not obvious.Both X/Y Overview Plot PCA analysis and Loading Scatter Plot indicated hemoglobin,hematocrit,and average hemoglobin content had the greatest significance in judging spleen deficiency syndrome in patients with lean NAFLD.Conclusion Although erythrocyte system parameters are highly correlated with spleen deficiency syndrome,routine laboratory tests may not accurately diagnose and differentiate patients with spleen deficiency syndrome in type NAFLD.
作者
蒋元烨
孙沛祺
袁乙富
杜晟楠
何诗嘉
华红梅
JIANG Yuanye;SUN Peiqi;YUAN Yifu;DU Shengnan;HE Shijia;HUA Hongmei(Department of Gastroenterology,Putuo District Central Hospital,Shanghai 200062,China;Shanghai Baiyu Community Health Service Center,Shanghai 200333,China)
出处
《中国医药导报》
CAS
2024年第12期20-26,共7页
China Medical Herald
基金
上海市自然科学基金资助项目(22ZR1455900)
上海市普陀区卫生健康系统科技创新重点项目(ptkwws202201)
上海市普陀区杏林优青人才培养计划项目(ptxlyq2201)。
关键词
瘦型非酒精性脂肪性肝病
脾虚证
临床特点
相关性
Lean non alcoholic fatty liver disease
Spleen deficiency syndrome
Clinical features
Correlation
