摘要
目的探讨孕中期检测血清25-羟维生素D[25(OH)D]对于预测妊娠期糖尿病(GDM)的价值。方法回顾性分析2022年1月至2023年3月广东省东莞康华医院产科接受检查的2000例孕妇的临床资料。均在妊娠中期时刻采集静脉血液,离心分离血清,电化学发光免疫分析仪测定血清25(OH)D含量。根据血清25(OH)D含量分为充足组[血清25(OH)D含量≥75 nmol/L]、适宜组[50 nmol/L≤25(OH)D<75 nmol/L]、不足组[25 nmol/L≤25(OH)D<50 nmol/L]、缺乏组[25(OH)D<25 nmol/L],比较各组GDM发生情况,针对不同血清25(OH)D含量组发生GDM者血糖结果进行分析,并且采取Pearson相关性分析GDM患者血糖异常同血清25(OH)D水平关联。结果2000例孕妇检测出GDM例数为278例,检出率为13.90%;缺乏组与不足组GDM的发生率均高于充足组、适宜组,差异有统计学意义(P<0.05),而缺乏组GDM发生率高于不足组,差异有统计学意义(P<0.05)。278例孕妇诊断为GDM,其中143例孕妇有其他高危因素,135例无高危因素。对无高危因素的孕妇测定不同时间点的血糖结果,葡萄糖耐量试验(OGTT)后1 h血糖异常的比例比较,差异无统计学意义(P>0.05),OGTT后2 h,缺乏组与不足组血糖异常比例均高于充足组与适宜组,差异有统计学意义(P<0.05),而缺乏组血糖异常比例高于不足组,差异有统计学意义(P<0.05)。结论孕中期测定血清25(OH)D可早期预测GDM。
Objective To investigate the value of detecting serum 25-hydroxyvitamin D(25[OH]D)during the second trimester in the prediction of gestational diabetes mellitus(GDM).Methods The clinical data of 2000 pregnant women who were examined in the Department of Obstetrics of Dongguan Kanghua Hospital,Guangdong Province from January 2022 to March 2023 were analyzed retrospectively.The venous blood was collected during the second trimester of pregnancy,serum was separated by centrifugation,and the content of serum 25(OH)D was determined by electrochemiluminescence immunoassay.According to the serum 25(OH)D content,they were divided into the sufficient group(serum 25[OH]D content≥75 nmol/L),the suitable group(50 nmol/L≤25[OH]D<75 nmol/L),the insufficient group(25 nmol/L≤25[OH]D<50 nmol/L)and the deficient group(25[OH]D<25 nmol/L).The occurrence of GDM was compared in all groups.The blood glucose results of patients with GDM in different serum 25(OH)D content groups were analyzed,and Pearson correlation analysis was used to analyze the correlation between abnormal blood glucose and serum 25(OH)D levels in patients with GDM.Results There were 278 cases of GDM in 2000 pregnant women,and the detection rate was 13.90%.The incidence rates of GDM in the deficient group and the insufficient group were all higher than those in the sufficient group and the suitable group,with statistically significant difference(P<0.05).While the incidence rate of GDM in the deficient group was higher than that in the insufficient group,with statistically significant difference(P<0.05).A total of 278 pregnant women were diagnosed with GDM,in which 143 pregnant women with other high-risk factors and 135 pregnant women without high-risk factors.There was no statistically significant difference in the proportion of abnormal blood glucose at 1 h after oral glucose tolerance test(OGTT)in pregnant women without high risk factors at different time points(P>0.05).At 2 h after OGTT,the proportions of abnormal blood glucose in the deficient group and the insufficient group were all higher than those in the sufficient group and the suitable group,with statistically significant difference(P<0.05).However,the proportion of abnormal blood glucose in the deficient group was higher than that in the insufficient group,with statistically significant difference(P<0.05).Conclusion Determination of serum 25(OH)D during the second trimester can help predict GDM early.
作者
黎自领
钟华丹
刘少英
LI Ziling;ZHONG Huadan;LIU Shaoying(Department of Obstetrics,Dongguan Kanghua Hospital,Guangdong,Dongguan 523000,China)
出处
《中国医药科学》
2024年第9期144-147,共4页
China Medicine And Pharmacy
基金
广东省东莞市社会发展科技项目(20211800903322)。
关键词
孕中期
25-羟维生素D
妊娠期糖尿病
维生素D
Second trimester
25-hydroxyvitamin D
Gestational diabetes mellitus
Vitamin D
