摘要
子痫前期是导致孕产妇死亡的第二大原因,对子痫前期的基础病因研究一直是研究的热点。关于子痫前期的体内研究,主要在于如何建模能够全面了解该病的发生发展过程以及对胎仔的影响,国内外研究者通常采用动物建模的方式进行研究,建模方法一般包括生物造模、手术造模、物理造模等,但单一的造模方法仍无法完全复制出与人类相同的模型,还需根据研究方向及预期结果,选择较合适的造模方法。
Preeclampsia is the second leading cause of maternal mortality,pathophysiological research on the etiology of preeclampsia has long been a hot topic.About the in vivo research in the pre-eclampsia,mainly lies in how to build a animal model,appropriated animal model can be helpful for fully understanding the occurrence and development of the disease and its impact on the fetal litter,domestic and foreign researchers usually use animal models to study,modeling methods generally include biological modeling,surgical modeling,physical modeling,etc.,but a single modeling method still can not completely produce the same animal preeclampsia model as humans,but also need to choose a more appropriate modeling method according to the research purpose and expected results.
作者
徐璟
王秀
XU Jing;WANG Xiu(the Second Clinical Medical College,Shaanxi University of Traditional Chinese,Xianyang 712046,China;Xi’an People’s Hospital,Xi’an Fourth Hospital,Xi’an 710004,China)
出处
《实验动物科学》
2024年第2期102-108,共7页
Laboratory Animal Science
基金
西安市第五批科技计划项目(2016052SF/YX08)。
关键词
子痫前期
动物造模
病理改变
preeclampsia
animal modeling
pathological changes
