摘要
目的探讨内脏脂肪组织(VAT)、腹部皮下脂肪组织(ASAT)、臀部脂肪组织(GFAT)与腔隙性脑梗死(LI)之间的因果关系。方法基于大样本的全基因组关联研究(GWAS)采用孟德尔随机化的方法探讨,肥胖指标与LI发生危险的因果关系:数据来源于两项独立的大样本GWAS研究数据库(CMDKP Consortium,CDKP Consortium)。结果GFAT与LI之间存在显著的因果关系,调整过的GFAT体积每增加1倍标准差,LI的风险降低25.2%(OR=0.748,95%CI 0.64~0.876,P=0.00029);本研究未发现VAT、ASAT与LI之间存在因果关系(P>0.05)。结论GFAT是LI的保护因素。
Objective Our study aimed to investigate the causal relationship between adipose distribution(visceral adpose tissue,abdominal subcutaneous adpose tissue),gluteofemoral adpose tissue and lacunar stroke.Methods We conducted Mendelian Randomization(MR)based large genome-wide association study(GWAS)to investigate the causal relationship between obesity indicators and lacunar stroke risk.Data were obtained from two independent large GWAS studies(CMDKP Consortium,CDKP Consortium).Results There is a significant causal relationship between gluteofemoral adpose tissue and lacunar infarction.The IVW analysis results indicated that the lacunar infarction risk was decreased by 25.2%(0R=0.748,95%CI 0.64-0.876,P=0.00029)with one-standard deviation(1-SD)increase in the voume of gluteofemoral adpose.No causal relationship was found between visceral adipose tissue,abdominal subcutaneous adipose tissue and infarction(P>0.05).Conclution Gluteofemoral adpose tissue is a protective factor for lacunar infarction.
作者
贾鸿宁
Jia Hongning(Department of Neurology,Cangzhou Central Hospital,Hebei 061000,China)
出处
《脑与神经疾病杂志》
CAS
2024年第5期279-283,共5页
Journal of Brain and Nervous Diseases
