摘要
目的抗γ氨基丁酸B型受体(GABABR)脑炎四例,以减少临床误诊误治。方法收集4例曾初诊为其他疾病的抗GABABR脑炎的临床资料,并分析其临床特征及误诊原因。结果4例患者均有癫痫发作及认知障碍,2例(例2、例4)伴发精神症状。4例颅脑MRI均发现单侧或双侧颞叶病变。初步诊断分别为胶质瘤3例和短暂性脑缺血发作1例(例4)。误诊时间为12~68d。结论抗GABABR脑炎的临床特征与其他疾病存在交叉,提高对该疾病的认识、尽早完善特异性抗体检查是明确诊断的关键,从而减少临床误诊误治。
Objective To review the cases of anti-gamma-aminobutyric acid B-type receptor(GABABR)encephalitis in order to reduce clinical misdiagnosis and mistreatment.Methods The clinical data of 4 cases of anti-GABABR encephalitis misdiagnosed as other diseases were collected and analyzed.Results All the 4 patients had epileptic seizure and cognitive impairment,including 2 patients(case 2,case 4)with psychiatric symptoms.Unilateral or bilateral temporal lobe lesions were found in all the 4 cases.The preliminary diagnosis was glioma in 3 cases and transient ischemic attack in 1 case(case 4).The misdiagnosis time was 12-68 days.Conclusion The clinical manifestations and auxiliary examination of Anti-GABABR encephalitis overlap with other diseases.Improving the understanding of the disease and perfecting the specific antibody examination as soon as possible are the key to avoid misdiagnosis.
作者
陈晓莉
张国平
王群
李静
杨燕芳
Chen Xiaoli;Zhang Guoping;Wang Qun;Li Jing;Yang Yanfang(Department of Neurology,Shaanxi Provincial People's Hospital,Xi'an 710008,China)
出处
《脑与神经疾病杂志》
CAS
2024年第5期271-275,共5页
Journal of Brain and Nervous Diseases
基金
国家自然科学基金面上项目(81471225)
湖南省发改委计划项目[2021]212号40。
关键词
抗γ氨基丁酸B型受体
磁共振成像
胶质瘤
短暂性脑缺血发作
Anti-gamma aminobuturic acid type B receptor
Magnetic resonance imaging
Glioma
Transientischemicattacks
