摘要
重组人尿激酶原(rhPro-UK)已被广泛应用于治疗各种血栓性疾病,其疗效显著且无明显不良反应,在多个新技术领域也得到了广泛的应用。本文重点介绍了rhPro-UK在急性心肌梗死、脑血管疾病、下肢深静脉血栓形成、动脉血栓形成等疾病治疗中的应用情况。rhPro-UK在这些疾病中表现出良好的溶栓效果和安全性,尤其是在急性心肌梗死患者中,辅助经皮冠状动脉介入治疗可以显著提高心肌再灌注,改善心功能,且不增加出血风险。针对脑血管病,rhPro-UK可显著改善神经功能缺损程度,安全性也较高。在下肢深静脉血栓形成治疗中,rhPro-UK相较于尿激酶显示出更优的溶栓效果和安全性。对于动脉血栓形成和生物支架方面,rhPro-UK的应用也取得了一定疗效,但还需要更多的研究来证实其有效性和安全性。此外,超声介导的载药溶栓系统在rhPro-UK治疗中也具有潜在的应用前景,对于rhPro-UK未来的研究重点将会更加集中在新技术的开发上。
In recent years,recombinant human urokinase(rhPro-UK)has been widely used in the treatment of a variety of thromboembolic diseases,with significant efficacy and no obvious adverse reactions.In addition,it has a wide range of applications in many new technology fields.This article focuses on the application of rhPro-UK in the treatment of acute myocardial infarction,cerebrovascular disease,lower extremity deep vein thrombosis,arterial thrombosis and other diseases.rhPro-UK has demonstrated good thrombolytic efficacy and safety in these diseases,especially in patients with acute myocardial infarction,and adjuvant PCI therapy can significantly increase myocardial reperfusion,improve cardiac function,and do not increase the risk of bleeding.For cerebrovascular disease,rhPro-UK can significantly improve the degree of neurological deficit and has a high safety profile.In the treatment of lower extremity deep vein thrombosis,rhPro-UK has shown superior thrombolytic efficacy and safety compared with urokinase.For arterial thrombosis and biological stents,the use of rhPro-UK has also achieved some efficacy,but more research is needed to confirm its efficacy and safety.In addition,ultrasound-mediated drug-loaded thrombolysis systems also have potential applications in rhPro-UK therapy.Future research on rhPro-UK will focus more on the development of new technologies.
作者
李子兴
毅力起
高占峰
Li Zixing;Yi Liqi;Gao Zhanfeng(Department of Vascular Surgery,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010059,China)
出处
《国际外科学杂志》
2024年第3期212-216,共5页
International Journal of Surgery
基金
内蒙古医科大学附属医院一般科研项目(NYFY YB 011)。
关键词
血栓溶解疗法
血栓栓塞
药物洗脱支架
声学微泡
重组人尿激酶原
Thrombolytic therapy
Thromboembolism
Drug-eluting stents
Acoustic microbubbles
Recombinant human urokinase
