摘要
Isthmin-1(ISM1)属于Isthmin基因家族,在多种组织中均有表达,具有多种生物学功能。研究显示ISM1参与生长发育、代谢、免疫、肿瘤发生等生理病理过程,与ARDS、COPD、肺纤维化等多种肺部疾病存在关联。该文就ISM1的结构、生物学功能及其在肺部疾病中的作用进行综述,旨在为ISM1相关疾病的诊断及治疗提供理论基础。
Isthmin-1(ISM1)belongs to the Isthmin gene family.It is expressed in various tissues and has multiple biological functions.ISM1 is involved in growth and development,metabolism,immunity,tumorigenesis and other physiological and pathological processes,which is associated with a variety of lung diseases,including acute respiratory distress syndrome,chronic obstructive pulmonary disease and pulmonary fibrosis,etc.In this article,the structure,biological function of ISM1 and its role in pulmonary diseases were reviewed,aiming to provide a theoretical basis for the diagnosis and treatment of ISM1-related diseases.
作者
孙淑琪
崔学芬
王瑶瑶
王洪梅
王雨阳
于新娟
Sun Shuqi;Cui Xuefen;Wang Yaoyao;Wang Hongmei;Wang Yuyang;Yu Xinjuan(School of Clinical Medicine,Weifang Medical University,Weifang 261053,China)
出处
《新医学》
CAS
2024年第3期184-187,共4页
Journal of New Medicine
基金
山东省自然科学基金生物医学联合基金(ZR2021LSW027)
潍坊医学院研究生科研创新基金(2022YJSCX018)。
