摘要
内质网应激(ERS)诱导的细胞凋亡与多种疾病有关,而免疫球蛋白结合重链蛋白在ERS中发挥重要作用。多种麻醉药物通过ERS通路产生神经保护作用,其中丙泊酚具有明确的神经保护作用,右美托咪定可抑制ERS产生神经保护作用,氯胺酮可抑制ERS改善神经性疼痛,七氟烷也具有神经保护作用。此外,不同麻醉药物对ERS通路的影响不同,但目前麻醉药物神经保护作用机制尚未明确,仍需要进一步进行基础实验和临床试验研究。
Endoplasmic reticulum stress(ERS)induced cell apoptosis is associated with various diseases,and immunoglobulin binding heavy chain proteins play an important role in ERS.Various anesthetic drugs produce neuroprotective effects through the ERS pathway,among which propofol has a clear neuroprotective effect,dexmedetomidine can inhibit the ERS and generate neuroprotective effect,ketamine can inhibit ERS and improve neuropathic pain,and sevoflurane also has neuroprotective effect.In addition,different anesthetic drugs have different effects on the ERS pathway,but their neuroprotective mechanism is not yet clear,and further basic experiment and clinical research is needed.
作者
王烨
佟世义
杨冬
邓晓明
WANG Ye;TONG Shiyi;YANG Dong;DENG Xiaoming(Department of Anesthesiology,Plastic Surgery Hospital,Chinese Academy of Medical Sciences Peking Union Medical College,Beijing 100144,China)
出处
《医学综述》
CAS
2024年第5期630-635,共6页
Medical Recapitulate
关键词
内质网应激
麻醉药物
神经保护
Endoplasmic reticulum stress
Anesthetic drugs
Neuroprotection
