摘要
目的探究超声造影(CEUS)与动态增强磁共振成像(DCE-MRI)对乳腺癌患者新辅助化疗(NAC)的评估价值。方法选取2020年1月~2023年1月于我院接受NAC的乳腺癌患者68例,对所有入选患者NAC治疗后行CEUS、DCE-MRI检查,以手术病理结果为金标准,将治疗后患者分为有效组与无效组,比较CEUS、DCE-MRI以及两者联合对乳腺癌患者NAC疗效的评估价值,对比有效组与无效组CEUS、DCEMRI检查的参数水平。结果68例乳腺癌患者NAC后,经手术病理诊断发现49例有效,19例无效。采用CEUS检查评估NAC疗效的敏感性、特异性及准确性分别为81.63%、68.42%、67.65%,经手术病理评估为有效患者的峰值强度(PI)、曲线下面积(AUC)水平低于无效患者(P<0.05);采用DCE-MRI检查时的敏感性、特异性及准确性分别为83.67%、73.68%、67.65%,经手术病理评估为有效患者的容量转移常数(K^(trans))、速率常数(K_(ep))均低于无效患者(P<0.05)。CEUS联合DCE-MRI评估NAC疗效的敏感性及准确性分别为97.96%、94.83%,均显著高于单一检查方法(P<0.05)。结论CEUS联合DCE-MRI能提高对乳腺癌患者NAC疗效的评估价值,其敏感性及准确性较高,值得推广。
Objective To investigate the value of contrast-enhanced ultrasound(CEUS)and dynamic contrastenhanced magnetic resonance imaging(DCE-MRI)in evaluating neoadjuvant chemotherapy(NAC)of breast cancer patients.Methods A total of 68 breast cancer patients who underwent NAC in the hospital from January 2020 to January 2023 were selected.All patients enrolled were examined with CEUS and DCE-MRI after NAC.With surgical and pathological results as the golden standard,the patients were divided into effective group and ineffective group.The value of CEUS,DCE-MRI,and their combination in evaluating the efficacy of NAC in breast cancer patients was compared.CEUS parameters and DCE-MRI parameters were compared between the effective group and the ineffective group.Results Surgical and pathological results showed that there were 49 cases in the effective group and 19 cases in the ineffective group.The sensitivity,specificity and accuracy of CEUS for evaluating the efficacy of NAC were 81.63%,68.42%and 67.65%.The peak intensity(PI)and the area under the curve(AUC)of effective group were lower than those of ineffective group(P<0.05).The sensitivity,specificity and accuracy of DCE-MRI were 83.67%,73.68%and 67.65%.The volume transfer constant(K^(trans))and rate constant(K_(ep))of effective group were lower than those of ineffective group(P<0.05).The sensitivity and accuracy of CEUS combined with DCE-MRI for evaluating the efficacy of NAC were 97.96%and 94.83%,significantly higher than those of single evaluation(P<0.05).Conclusion CEUS combined with DCE-MRI can improve efficacy evaluation of NAC in patients with breast cancer,with high sensitivity and accuracy.
作者
叶细容
江峰
洪玮
YE Xi-rong;JIANG Feng;HONG Wei(Department of Ultrasound Imaging,Huangshi Central Hospital(Affiliated Hospital of HubeiUniversity of Technology),Huangshi 435000,Hubei Province,China;Department of Ultrasound Imaging,Yijishan Hospital Affiliated to Wannan Medical College,Wuhu 241004,Anhui Province,China)
出处
《中国CT和MRI杂志》
2024年第2期95-97,共3页
Chinese Journal of CT and MRI
基金
湖北省科学技术厅(2022CFD066)。
关键词
超声造影
动态增强磁共振成像
乳腺癌
新辅助化疗
评估价值
Contrast-enhanced Ultrasound
Dynamic Contrast-Enhanced Magnetic Resonance Imaging
Breast Cancer
Neoadjuvant Chemotherapy
Evaluation Value
