摘要
通过发酵生产工业产品一直是细菌等微生物的研究热点,但是发酵过程中存在的代谢副产物和环境胁迫等问题,限制了工业菌株的发展。sRNA是细菌中普遍存在的一类调控性非编码RNA,它们与核糖开关、双组分系统、转录因子等其他调控元件共同构成了细菌中的复杂调控网络,在代谢调控和抗胁迫中都发挥着异常重要的作用。文章对细菌中sRNA的来源、作用机制以及在调控网络中的角色进行了详细总结,有助于更好地解析细菌的代谢途径及发酵过程中受到的环境限制,对构建低毒力、高鲁棒性菌株,助力工业产品的发酵生产有重要参考意义。
The production of industrial products by fermentation has always been a hot topic in the research of bacteria and other microorganisms,but the development of industrial strains is limited by the metabolic by-products and environmental stress in the fermentation process.sRNAs are a common class of non-coding RNAs in bacteria.Together with riboswitches,two-component systems,transcription factors and other regulatory elements,they constitute a complex regulatory network in bacteria.sRNAs play an extremely important role on metabolic regulation and stress resistance.The sources,mechanisms and roles of sRNA in the regulatory network of bacteria are summarized in this review,which contributes to analyzing the metabolic pathway of bacteria and environmental stress during the fermentation process.It has important reference significance for the construction of low virulence and high robustness strains,so as to promote the development of fermentation industry.
作者
赵子墨
乔建军
袁琳
龙映鹏
任书江
吴昊
ZHAO Zimo;QIAO Jianjun;YUAN Lin;LONG Yingpeng;REN Shujiang;WU Hao(School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China;Zhejiang Institute of Tianjin University,Shaoxing,Shaoxing 312300,China;College of Food Science and Bioengineering,Tianjin Agricultural University,Tianjin 300384,China;College of Animal Science and Veterinary Medicine,Tianjin Agricultural University,Tianjin 300384,China)
出处
《食品与发酵工业》
CAS
CSCD
北大核心
2024年第3期290-297,共8页
Food and Fermentation Industries
基金
国家自然科学基金项目(32070073)。
