摘要
大脑是人体内具有高代谢需求的重要器官,而癫痫作为一种较为常见的神经系统疾病,其病灶区域也表现出了高代谢特征。目前,通过调节代谢的方式对耐药性癫痫或特定代谢缺陷引起的癫痫发作进行控制,展现出了良好的抗癫痫效果。近年来人们对脑的代谢与癫痫发作之间的关系越来越感兴趣,迄今为止,已经提出了几种针对代谢途径的新型抗癫痫疗法(即抑制糖酵解、靶向乳酸脱氢酶和饮食疗法)。通过调节脑的新陈代谢的方式对癫痫进行干预,是非常有希望可以得到预期结果的,然而目前我们对于大脑代谢在控制癫痫中的作用仍然缺乏透彻的了解。本综述旨在深入了解有关大脑的能量代谢及其与癫痫的相关性,强调通过糖酵解调节神经元兴奋性,据此寻找有效的抗癫痫疗法,以便更好地理解糖酵解在癫痫发作中的作用,并揭示潜在的癫痫治疗靶点。
The brain is an important organ in the human body with high metabolic requirements,and epilepsy,as a common neurological disease,also exhibits high metabolic characteristics in its lesion area.At present,controlling seizures caused by drug-resistant epilepsy or specific metabolic defects through metabolic regulation has shown good anti epileptic effects.In recent years,people have become increasingly interested in the relationship between brain metabolism and epileptic seizures.So far,several new anti epileptic therapies targeting metabolic pathways have been proposed,including inhibition of glycolysis,targeted lactate dehydrogenase,and dietary therapy.It is highly promising to intervene in epilepsy by regulating brain metabolism,but currently we still lack a thorough understanding of the role of brain metabolism in controlling epilepsy.This review aims to gain a deeper understanding of energy metabolism in the brain and its correlation with epilepsy,emphasizing the regulation of neuronal excitability through glycolysis,in order to search for effective anti epileptic therapies,in order to better understand the role of glycolysis in epileptic seizures and reveal potential therapeutic targets for epilepsy.
作者
吕邵敏
郭佳
刘瑞寒
孔庆霞
Lyu Shaomin;Guo Jia;Liu Ruihan;Kong Qingxia(Clinical Medicine College,Jining Medical University,Jining 272100,China;Department of Neurology,Affiliated Hospital of Jining Medical University,Jining 272100,China)
出处
《中国医师杂志》
CAS
2023年第12期1913-1916,共4页
Journal of Chinese Physician
基金
山东省自然科学基金(ZR2019MI1060)
济宁市重点研发计划项目(2019SMNS019)。
关键词
糖酵解
癫痫
能量代谢
Glycolysis
Epilepsy
Energy metabolism
