摘要
目的 观察盐酸小檗碱片联合复方谷氨酰胺治疗溃疡性结肠炎(UC)的效果,并探讨其机制。方法 纳入UC患者102例,随机分为2组。对照组51例给予常规治疗+复方谷氨酰胺,试验组51例在对照组基础上给予盐酸小檗碱片,2组均治疗8周。比较2组的疗效、改良Mayo评分、肠黏膜屏障功能、可溶性晚期糖基化终末产物受体(sRAGE)、白细胞介素(IL)-17、IL-6及不良反应发生情况。结果 试验组总有效率高于对照组(92.2%vs. 76.5%,P<0.05)。治疗后,2组改良Mayo评分中的排便次数、便血、内镜发现、医师总体评价评分,二胺氧化酶(DAO)、D-乳酸、内毒素、s RAGE、IL-17、IL-6均低于治疗前,且试验组低于对照组(P<0.05)。2组不良反应总发生率差异无统计学意义(P>0.05)。结论 盐酸小檗碱片联合复方谷氨酰胺治疗UC疗效确切,未增加不良反应。
Objective To investigate the effect of berberine hydrochloride tablets combined with compound glutamine in treating ulcerative colitis(UC).Methods One hundred and two patients with UC admitted to our hospital were collected and grouped into two groups according to the random number table.Fifty-one patients in the control group were given conventional treatment+compound glutamine,and 51 patients in the experimental group were given berberine hydrochloride tablets based on the control group.Both groups were treated for 8 weeks.The efficacy,modified Mayo score,intestinal mucosal barrier function,soluble late glycation end product receptor(sRAGE),interleukin-17(IL-17),IL-6 and incidence of untoward reactions were compared between the two groups.Results The total effective rate of the experimental group was higher than that of the control group(92.2%vs.76.5%,P<0.05).After treatment,scores of defecation frequency,blood in stool,endoscopic findings,physician´s overall evaluation,diamine oxidase(DAO),D-lactic acid,endotoxin,sRAGE,IL-17 and IL-6 were lower in both groups than those before treatment(P<0.05),and the research group was lower than the control group(P<0.05).There was no significant difference in the total incidence of untoward reactions between the experimental group and the control group(P>0.05).Conclusion Berberine hydrochloride tablets combined with compound glutamine are effective in treating UC,which can reduce the activity of UC,improve the intestinal mucosal barrier function,regulate serum sRAGE,IL-17 and IL-6 levels,without increasing adverse reactions.
作者
张萌
崔瑞洁
李彩芳
高琦
李斐
ZHANG Meng;CUI Ruijie;LI Caifang;GAO Qi;LI Fei(Department of Pharmacy,Xinxiang Central Hospital,Xinxiang 453000,China;Department of Gastroenterology,Xinxiang Central Hospital,Xinxiang 453000,China;Clinical Laboratory,Xinxiang Central Hospital,Xinxiang 453000,China)
出处
《天津医药》
CAS
2024年第1期102-106,共5页
Tianjin Medical Journal
关键词
小檗碱
谷氨酰胺
结肠炎
溃疡性
肠黏膜屏障
Berberine
glutamine
colitis,ulcerative
intestinal mucosal barrier
