摘要
糖尿病足溃疡(Diabetic foot ulceration,DFU)是糖尿病常见并发症,也是导致患者病情恶化、截肢甚至死亡的重要原因。彻底清创、控制感染、重建血运和及时修复创面是DFU的治疗重点。目前抗生素骨水泥已被用于治疗DFU创面,并且取得了满意的效果。本文通过分析总结现有的文献,发现抗生素骨水泥用于DFU中的常用策略为:一期彻底清创后用抗生素骨水泥覆盖创面以控制感染,促进诱导膜生成;二期采用植皮、皮瓣移植、Ilizarov技术等修复创面。此外,本文列举相关抗生素骨水泥材料与多种辅助治疗技术的联合治疗,为临床治疗提供多种选择参考。
Diabetic foot ulceration(DFU)is a common complication in diabetic patients and an important cause of deterioration,amputation and even death.Thorough debridement,infection control,re-establishment of blood flow and timely repair of the wound are the mainstays of treatment for DFU.Antibiotic bone cement has been used to treat DFU wounds with satisfactory results.In this paper,the available literature was analyzed and found that the common strategy for the use of antibiotic bone cement in DFU is to cover the wound with antibiotic bone cement to control infection and promote induction membrane production after complete debridement in phase 1,and to repair the wound with skin grafting,flap grafting and Ilizarov technique in phase 2.In addition,the relevant adjuvant treatments were listed based on antibiotic bone cement materials to provide a variety of options for clinical treatment.
作者
刘陈肖笑
简扬
张演基
魏在荣
LIU-CHEN Xiaoxiao;JAN Yang;ZHANG Yanji;WEI Zairong(Department of Burns and Plastic Surgery,Affiliated Hospital of Zunyi Medical University,The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University,Zunyi 563003,China)
出处
《组织工程与重建外科》
CAS
2023年第6期591-596,共6页
Journal of Tissue Engineering and Reconstructive Surgery
基金
省部共建协同创新中心项目(2020-39)
贵州省科技计划项目(2020-5012)
合肥市科技计划项目(2021-3)
贵州茅台医院科研与人才培养资金。
关键词
糖尿病足溃疡
抗生素骨水泥
清创术
感染
Diabetic foot ulcer
Antibiotic bone cement
Debridement
Infection
