摘要
目的 :观察氧氟沙星聚乳酸缓释植入药栓眼内组织相溶性及生物降解过程。方法 :将自制的氧氟沙星聚乳酸缓释药栓经平坦部巩膜切口植入 1 1只兔眼玻璃体腔 ,进行眼电生理检测和电镜及光镜检查。结果 :药栓植入前后 b波振幅差异无显著 ( P>0 .0 5 ) ;药栓植入后 7d和 2 1 d电镜和光镜检查视网膜组织无病理性改变 ;药栓植入早期眼组织有轻微异物性炎症反应 ,药栓逐渐降解吸收。结论 :氧氟沙星聚乳酸缓释药栓在眼内玻璃体腔具有良好的组织相溶性 。
Objective:To study the histocompatibility and biodegredation of implantable ofloxacine sustained released suppositoria in rabbit eyes. Methods:Ofloxacine sustained released suppositories were implanted into the vitreous cavity of 11 rabbit eyes, and ERG measurements were underwent 1~3 d before and 3~26 d after the procedure. Total biopsy including electromicroscope near the inner layer of the rabbit eyeball was underwent 7 d and 21 d after the procedure. Tissue reaction and biodegredation of the suppositoria were evaluated through biopsy 2~14 week after the procedure. Results:Amplitudes of B wave were the same before and after the procedure ( P >0.05). By means of the microscopy and electromicroscopy, pathological lesion was not found 7 d and 21 d after the procedure. Mild inflammatory reaction was found in the early period after the procedure and was absorbed when the drug was degraded gradully. Conclusion: There is a good histocompatibility and biodegredation of implantable of loxacine sustained released suppositoria in the vitreous cavity.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2002年第6期616-617,共2页
Journal of Jilin University：Medicine Edition
基金
深圳市科技局资助课题 (19980 5 0 17)
