摘要
目的了解人感染H7N9禽流感病例的临床特征及危险因素,为降低其病死率提供参考依据。方法以安徽医科大学某医院2014—2017年确诊的12例人感染H7N9禽流感病例为研究对象,比较存活组与死亡组的基础资料、实验室检测指标和影像学资料等之间的差异。结果12例人感染H7N9禽流感确诊病例,死亡3例;男性发病率高于女性,男女性别比为11∶1;平均年龄为(56.42±13.24)岁;有基础性疾病者7例。存活组与死亡组在人群性别、禽类接触史、基础性疾病患病情况、发病就诊情况、临床表现、早期实验室检测结果等方面差异均无统计学意义(均P>0.05),但在年龄和是否进展为多器官功能障碍综合征等方面差异有统计学意义(P<0.05)。结论老年男性是感染H7N9禽流感的高危人群,合并多种基础性疾病是其死亡的高危因素,早发现、早诊断和早治疗对于降低其病死率有重要意义。
Objective To understand the clinical characteristics and risk factors of human infection with avian influenza H7N9,and to provide a reference basis for reducing the fatality rate.Methods A total of 12 cases of human infection with avian influenza H7N9 diagnosed in a hospital of Anhui Medical University from 2014 to 2017 were selected as the study subjects to compare the differences inbasic information,laboratory test indexes and imaging data between the survival group and the death group.ResultsOf the 12 confirmed cases of human infection with avian influenza H7N9,3 cases died.The incidence rate was higher in males than that in females,with a male-to-female gender ratio of 11:1 an average age of(56.42±13.24)years,and 7 patients with underlying diseases.There was no statistically significant difference between the survival group and the death group in gender of the population,poultry contact history,incidence of underlying diseases,onset and treatment,clinical manifestations and early laboratory test results(all P>0.05),but there were statistically significant differences between age and progression of multiple organ dysfunction syndrome and other aspects(P<0.05).Conclusion Elderly men are at high risk of infection with H7N9 avian influenza,and complicated with multiple underlying diseases is a high risk factor for death.Early detection,diagnosis and treatment are of great significance to reduce the fatality rate.
作者
刘瑞
闫敏敏
魏嵘
张进
汪卓赟
郑凌
LIU Rui;YAN Minmin;WEI Rong;ZHANG Jin;WANG Zhuoyun;ZHENG Ling(The Second Afiliated Hospital of Anhui Medical University,Hefei,Anhui 230601,China;不详)
出处
《医学动物防制》
2023年第10期971-975,共5页
Journal of Medical Pest Control
基金
安徽省高等学校科学研究项目(2022AH050610)
安徽医科大学校科研基金项目(2022xkj312)。
关键词
H7N9禽流感
肺炎
临床特征
危险因素
分析
H7N9 Avian influenza
Pneumonia
Clinical characteristics
Risk factors
Analysis
