摘要
Measurable residual disease(MRD)has been widely recognized as a biomarker for deeply evaluating complete remission(CR),predicting relapse,guiding pre-emptive interventions,and serving as an endpoint surrogate for drug testing.However,despite the emergence of new technologies,there remains a lack of comprehensive understanding regarding the proper techniques,sample materials,and optimal time points for MRD assessment.In this review,we summarized the MRD methods,sample sources,and evaluation frequency according to the risk category of the European Leukemia Net(ELN)2022.Additionally,we emphasize the importance of properly utilizing and combining these technologies.We have also refined the flowchart outlining each time point for preemptive interventions and intervention paths.The evaluation of MRD in acute myeloid leukemia(AML)is sophisticated,clinically applicable,and technology-dependent,and necessitates standardized approaches and further research.
基金
supported by Beijing Nova Program of Science and Technology (No.Z211100002121058)
National Natural Science Foundation of China (No.82100168)
Peking University People’s Hospital Research and Development Funds (No.RS2020-03,RDY2020-29)
Peking University Medicine Fund of Fostering Young Scholars’ Scientific & Technological Innovation
“the Fundamental Research Funds for the Central Universities”(No.BMU2021PYB005)
