摘要
目的探讨C反应蛋白(CRP)在精神分裂症患者性别与认知功能间的中介效应。方法统计110例病情稳定的精神分裂症患者(男54例,女56例)的临床资料,采用认知功能成套测验(Stroop测验、范围流畅性测验、连线测验和木块图测验)测评患者的认知功能,采用免疫荧光检测血清CRP水平。采用Pearson相关分析法分析不同性别患者CRP水平与精神症状、认知功能的关系。采用SPSS PROCESS的自举方法(模型4中介效应分析)分析CRP是否介导性别和认知功能之间的联系。结果男性患者CRP水平及范围流畅性测验-动物、连线测验-B、木块图测验向后广度得分与女性患者相比,差异有统计学意义(P<0.05或0.01)。女性患者CRP水平与Stroop测验色词及范围流畅性测验-动作评分呈显著正相关(P<0.05或0.01),与连线测验-B评分呈显著负相关(P<0.05或0.01);男性患者CRP水平与精神症状及认知功能无显著相关性(P>0.05)。CRP对连线测验-B评分的负向预测作用显著(P<0.05或0.01)。Bootstrap结果显示,CRP在性别与连线测验-B评分间起部分中介作用,中介效应占总效应的20.10%。结论CRP在性别与认知功能中起部分中介作用,CRP对认知不同维度的预测作用因性别不同而存在差异。
Objective To explore the gender differences in the relationship between C-reactive protein(CRP)and cognitive functions in patients with schizophrenia.Methods Cognitive functions were evaluated using the MATRICS Consensus Cognitive Battery(MCCB)[Stroop Test(ST),Category Fluency(CF),Trail Making Test(TMT),and Block Diagram(BD)]in 110 clinically stable schizophrenics(male 54,female 56),serum C-reactive protein(CRP)levels detected via immunofluorescence.Pearson correlation analysis was used to analyze the relationships among the CRP,mental symptoms,and cognitive function win patients of different genders.The bootstrap method of SPSS PROCESS(model 4 mediation effect a nalysis)was used to explore whether CRP mediated the association between gender and cognitive function.Results Differences in CRP levels and the CF-animal,TMT-B,and BD backward span score between male and female patients were statistically significant(P<0.05 or 0.01).The CRP levels were significantly positively related to the scores on the Stroop colour-word and CF-action and negatively to TMT-B in female patients(P<0.05 or 0.01);there were no obvious correlations of CRP levels with mental symptoms and cognitive functions in male patients(P>0.05).Negative predictive effect of the CRP on TMT-B score was significant(P<0.05 or 0.01).Bootstrap results showed that the CRP was a partial mediator between gender and TMT-B,with a mediating effect accounting for 20.10%of the total effect.Conclusion The CRP is a partial mediator between gender and cognitive functions and the predictive effect of CRP levels on different dimensions of cognition varies depending on gender.
作者
丛小兵
陈宽玉
赵雅琴
肖文焕
Cong Xiaobing;Chen Kuanyu;Zhao Yaqin;Xiao Wenhuan(Yangzhou Wutaishan Hospital,Yangzhou 225003,Jiangsu,China)
出处
《临床心身疾病杂志》
CAS
2023年第6期28-32,50,共6页
Journal of Clinical Psychosomatic Diseases
基金
江苏省老年健康科研项目(编号LKM2022080)
扬州市科技计划-社会发展项目资助(编号YZ2020109)
扬州市“十三五”科教强卫专项经费资助(编号ZDRC201830)
扬州市护理学会软科学研究培育课题(编号202322)。
