摘要
近年研究发现,阿尔茨海默病(AD)和进行性核上性麻痹(PSP)等Tau蛋白病的病理改变均涉及突触囊泡传递或循环障碍。本文现围绕AD、PSP与突触囊泡循环障碍的关系探讨疾病的发病机制,以期为新药开发提供新的视角。
Recent studies have found that the pathological changes of Tau proteinopathy,such as Alzheimer's disease(AD)and progressive supranuclear palsy(PSP),involve transmission or circulatory disturbance of synaptic vesicles.This article reviews the relations of AD/PSP with circulatory disturbance of synaptic vesicles and explore the pathogenesis of these diseases,aiming to provide a new perspective for new therapeutic drugs.
作者
文雨彤
肖钰
田月琴
高筱雅
Wen Yutong;Xiao Yu;Tian Yueqin;Gao Xiaoya(Second Clinical Medical School,Southern Medical University,Guangzhou 510280,China;Department of Pediatric Neurology,Zhujiang Hospital,Southern Medical University,Guangzhou 510280,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2023年第10期1054-1058,共5页
Chinese Journal of Neuromedicine
基金
国家自然科学基金(81873776)
广东省自然科学基金(2021A1515011681、2023A1515010495)。
关键词
Tau蛋白病
突触囊泡循环
突触囊泡传递
阿尔茨海默病
进行性核上性麻痹
Tau proteinopathy
Synaptic vesicle cycle
Synaptic vesicle transmission
Alzheimer's disease
Progressive supranuclear palsy
