摘要
目的:基于网状Meta分析方法,对7种中成药联合常规西药治疗功能性消化不良(FD)的疗效及安全性进行评价。方法:计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库和PubMed,搜索中成药联合常规西药治疗FD的随机对照试验(RCT),检索时间为建库至2022年9月23日。由2名研究者独立筛选文献、提取资料、评价纳入研究的偏倚风险后,对符合质量标准的研究采用Stata 17.0软件进行分析。结果:最终纳入39项RCT研究,包括7种干预措施和3 718例患者。网状Meta分析结果显示,临床总有效率方面,累计概率排序依次为香砂平胃颗粒+常规西药>荆花胃康胶丸+常规西药>乌灵胶囊+常规西药>气滞胃痛颗粒+常规西药>达立通颗粒+常规西药>胃苏颗粒+常规西药>枳术宽中胶囊+常规西药>常规西药;提高血清胃动素水平方面,累计概率排序依次为枳术宽中胶囊+常规西药>胃苏颗粒+常规西药>香砂平胃颗粒+常规西药>达立通颗粒+常规西药>常规西药;提高血清胃泌素水平方面,累计概率排序依次为香砂平胃颗粒+常规西药>胃苏颗粒+常规西药>枳术宽中胶囊+常规西药>达立通颗粒+常规西药>常规西药;安全性方面,中成药联合常规西药的不良反应整体少于单纯使用常规西药治疗。结论:本研究初步评价了7种中成药在改善FD相关结局指标方面的疗效及排序情况,但由于纳入研究的局限性,方法学质量普遍不高,应谨慎选择用药,未来仍需开展更多高质量的RCT予以验证。
OBJECTIVE:To evaluate the efficacy and safety of 7 kinds of Chinese patent medicines combined with conventional western medicines in the treatment of functional dyspepsia(FD)by using network Meta-analysis.METHODS:CNKI,Wanfang Data,VIP,CBM and PubMed were retrieved to collect randomized controlled trials(RCT)of Chinese patent medicine combined with conventional western medicine in the treatment of FD.The retrieval time was from the establishment of the database to Sept.23rd,2022.After two researchers independently screened the literature,extracted the data,and evaluated the risk of bias in the included literature,Stata 17.0 software was used to analyze the studies that met the quality standards.RESULTS:Ultimately,39 RCT were enrolled,including 7 interventions and 3718 patients.Meta-analysis showed that in terms of total clinical effective rate,the cumulative probability was ranked in order of Xiangsha Pingwei granule+conventional western medicine>Jinghua Weikang capsule+conventional western medicine>Wuling capsule+conventional western medicine>Qizhi Weitong granule+conventional western medicine>Dalitong granule+conventional western medicine>Weisu granule+conventional western medicine>Zhizhu Kuanzhong capsule+conventional western medicine>conventional western medicine.In terms of increasing serum motilin levels,the cumulative probability was ranked in order of Zhizhu Kuanzhong capsule+conventional western medicine>Weisu granule+conventional western medicine>Xiangsha Pingwei granule+conventional western medicine>Dalitong granule+conventional western medicine>conventional western medicine.In terms of increasing serum gastrin levels,the cumulative probability was in order of Xiangsha Pingwei granule+conventional western medicine>Weisu granule+conventional western medicine>Zhizhu Kuanzhong capsule+conventional western medicine>Dalitong granule+conventional western medicine>conventional western medicine.In terms of safety,the adverse drug reactions of Chinese patent medicine combined with conventional western medicine were less than that of conventional western medicine alone.CONCLUSIONS:This study preliminarily evaluated the efficacy and sequencing of 7 kinds of Chinese patent medicines in improving FD related outcome indicators.However,due to the limitations of inclusion in the study,the quality of methodology is generally low,drug use should be carefully selected,and more high-quality RCT should be carried out in the future to verify.
作者
常雨
张艮霜
范明明
CHANG Yu;ZHANG Genshuang;FAN Mingming(Graduate School,Heilongjiang Academy of Chinese Medicine,Harbin 150036,China)
出处
《中国医院用药评价与分析》
2023年第10期1235-1240,1246,共7页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
“十四五”医药卫生规划重点课题“医疗卫生资源区域配置策略研究”(No.YYWS3938)
黑龙江省博士后资助经费项目(No.LBH-Z18274)
黑龙江中医药科研项目(No.ZHY18-043)。
关键词
功能性消化不良
中成药
网状Meta分析
Functional dyspepsia
Chinese patent medicine
Network Meta-analysis
