摘要
目的评价百癣夏塔热口服制剂治疗银屑病的有效性和安全性。方法利用PubMed、MEDLINE、万方数据知识服务平台(Wanfang Data)、维普全文数据库(VIP)、中国知网(CNKI)等数据库进行文献检索,时间从建库至2023年1月10日。文献质量由Cochrane协作网提供工具进行偏倚风险评估,利用Review Manager 5.4和Stata 17软件进行meta分析。结果本研究共纳入14篇文献,1427例患者。meta分析显示服用百癣夏塔热口服制剂的治疗组对于银屑病的治疗具有更高有效率[RR=1.24,95%CI(1.18,1.31),P<0.05],更低的银屑病面积和严重程度指数(PASI)评分[MD=-1.77,95%CI(-2.39,-1.15),P<0.05]。两组皮肤瘙痒的发生率差异无统计学意义(P=0.87),百癣夏塔热治疗组皮肤干燥的现象比常规治疗组患者少[RR=0.64,95%CI(0.43,0.97),P<0.05],发生腹泻的风险比常规治疗组患者更大[RR=6.69,95%CI(1.19,40.93),P<0.05]。结论服用百癣夏塔热口服制剂进行辅助治疗银屑病具有更好疗效,且安全性尚可。
Objective To assess the efficacy and s afety of oral form ulations of Baixuan Xiatare in the treatm ent of psoriasis.Methods Literature retrieval was conducted by PubMed,MEDLINE,Wanfang Data,VIP Full-text Database,CNKI and other databases from the establishment of the database to January 10,2023.The quality of the literature was assessed for risk of bias by tools provided by the Cochrane Collaboration Network.Metaanalysis was carried out using Review Manager 5.4 and Stata 17 software.Results 14 papers with a total of 1427 patients were included in the study after rigorous screening.The final meta-analysis demonstrated that the treatment group taking oral formulation of Baixuan Xiatare had a higher response rate(RR=1.24,95%CI[1.18,1.31],P<0.05)and lower psoriasis area and severity index(PASI)scores(MD=-1.77,95%CI[-2.39,-1.15],P<0.05).There was no significant difference between the two groups in the incidence of pruritus cutaneous(P=0.87),with less dry skin in the treatment group taking the oral formulation of Baixuan Xiatare(RR=0.64,95%CI[0.43,0.97],P<0.05)and a greater risk of diarrhoea than in the conventional treatment group(RR=6.69,95%CI[1.19,40.93],P<0.05).Conclusion The adjuvant treatment of psoriasis with the oral formulation of Baixuan Xiatare has relatively high levels of ef ficacy and safety.
作者
朱启豪
田江漫
李远
谭安军
易珍奎
温朝霞
ZHU Qihao;TIAN Jiangman;LI Yuan;TAN Anjun;YI Zhenkui;WEN Zhaoxia(Chongqing Yongchuan Hospital of Traditional Chinese Medicine,Chongqing 402160,China;Yongchuan Hospital of Chongqing Medical University,Chongqing 402160,China)
出处
《中国医药科学》
2023年第19期103-106,140,共5页
China Medicine And Pharmacy
