摘要
目前孤独症谱系障碍(ASD)的病因仍不明确,但通过表观遗传机制介导的基因-环境相互作用被认为是一个关键的促成因素。产前环境因素、组蛋白脱乙酰酶(HDAC)或乙酰化水平改变已被证明与ASD的发病风险增加有关。组蛋白乙酰化改变导致基因转录变化可能在ASD中起关键作用。此外,HDAC还与具有已知遗传病因的神经发育障碍有关,如癫痫、焦虑和智力障碍,这些神经发育障碍与ASD具有共同的临床特征和合并症。因此,明确HDAC与ASD的关系可为利用表观基因组减轻ASD症状的靶向治疗提供新思路。
The cause of autism spectrum disorder(ASD)remains unclear,but gene-environment interactions mediated by epigenetic mechanisms are thought to be a key contributing factor.Prenatal environmental factors,altered levels of histone deacetylase(HDAC),or acetylation have been shown to be associated with an increased risk of ASD.Changes in gene transcription due to histone acetylation changes may play a key role in ASD.In addition,HDAC has been associated with neurodevelopmental disorders with known genetic causes,such as epilepsy,anxiety,and intellectual disability,which share clinical features and comorbidities with ASD.Therefore,clarifying the effect of HDAC on ASD may provide new ideas for alleviating the symptoms of ASD by targeted therapy using epigenome.
作者
韩婷
竺智伟
HAN Ting;ZHU Zhiwei(Department of Developmental-behavioral Pediatrics,Children′s Hospital,Zhejiang University School of Medicine,Hangzhou 310051,China)
出处
《医学综述》
CAS
2023年第17期3358-3362,共5页
Medical Recapitulate
