摘要
In a recent Cancer Discovery publication,Bianchi et al.unveil a crucial mechanism driving therapeutic resistance in pancreatic ductal adenocarcinoma(PDAC),orchestrated by cell-autonomous Cxcl1 and TNF from polymorphonuclear myeloid-derived suppressor cells(PMN-MDSCs).This insight provides fresh perspectives for surmounting such resistance in PDAC.1 PDAC represents a highly aggressive malignancy exhibiting substantial therapeutic resistance,attributable to factors such as intractable genomic aberrations,immunosuppression mediated by myeloid cells,and pro-inflammatory activation of cancerassociated fibroblasts.
基金
This work was supported by National Natural Science Foundation of China(81901006)
Science and Technology Planning Project of Guangdong Province(2022A0505050038)
Scientific Research Talent Cultivation Project of Stomatological Hospital,Southern Medical University(RC202005)
Science Research Cultivation Program of Stomatological Hospital,Southern Medical University(PY2020002)。
