摘要
【目的】分析柴胡加龙骨牡蛎汤加减治疗女性肝郁型失眠疗效差异的影响因素。【方法】筛选87例符合纳入标准的女性肝郁型失眠患者,根据疗效情况分为缓解组和未缓解组,从一般资料和失眠主要症状两大方面进行单因素分析,再将差异有统计学意义的因素进行多因素分析,最后筛选出有统计学差异的影响因素。【结果】(1)分组情况:本研究选取的87例患者中,缓解组54例,未缓解组33例。(2)单因素分析结果提示:2组患者的抑郁程度、焦虑程度比较,差异有统计学意义(P<0.05或P<0.01);而2组患者的年龄分类、体质量指数(BMI)分类、失眠程度、学历程度、病程分类、入睡困难、多梦、早醒等比较,差异均无统计学意义(P>0.05)。(3)多因素分析结果提示:以不伴有焦虑状态(0级)和伴有轻度焦虑(1级)作为参照时,2组患者的中度焦虑程度差异有统计学意义(P<0.05或P<0.01)。【结论】相较于不伴有焦虑状态或伴有轻度焦虑的女性肝郁型失眠患者,柴胡加龙骨牡蛎汤加减对于伴有中度焦虑的女性肝郁型失眠患者短期疗效更好。
Objective To analyze the factors influencing the efficacy of modified Chaihu Plus Longgu Muli Decoction in treating female insomnia of liver-depression type.Methods Eighty-seven female insomnia patients with liver-depression type who met the inclusion criteria were divided into remission group and non-remission group according to their efficacy.A single-factor analysis was conducted on the two aspects of general information and the main symptoms of insomnia,and then the factors with statistically significant differences were included into the multi-factor analysis for the screening of the influencing factors with statistical differences.Results(1)Of the 87 patients,54 patients were allocated to the remission group and 33 patients were allocated to the nonremission group.(2)The results of the univariate analysis suggested that the differences in the degree of depression and anxiety were statistically significant between the two groups(P<0.05 or P<0.01),while the differences were not statistically significant in the age group,body mass index(BMI)classification,degree of insomnia,education level,the course of disease,difficulty in falling asleep,dreaminess and early awakening between the two groups(P>0.05).(3)The results of the multivariate analysis suggested that the difference in the moderate anxiety between the two groups was statistically significant(P<0.05 or P<0.01)when using the absence of anxiety status(level 0)and the presence of mild anxiety(level 1)as the reference.Conclusion Modified Chaihu Plus Longgu Muli Decoction exerts stronger short-term efficacy for the treatment of insomnia women with liver-depression type complicated with moderate anxiety than that of the liver-depression insomnia women without anxiety or with mild anxiety.
作者
张润发
徐大为
杨程杰
杜娅
李惠真
张志玲
ZHANG Run-Fa;XU Da-Wei;YANG Cheng-Jie;DU Ya;LI Hui-Zhen;ZHANG Zhi-Ling(The Fourth Clinical Medical School of Guangzhou University of Chinese Medicine,Shenzhen 518033 Guangdong,China;Shenzhen Traditional Chinese Medicine Hospital,Shenzhen 518033 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2023年第9期2231-2236,共6页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广东省自然科学基金项目(编号:2020A1515010775)
李惠林广东省名老中医药专家传承工作室建设项目
深圳市医疗卫生三名工程项目(编号:SZSM201512043)。
关键词
柴胡加龙骨牡蛎汤
失眠
肝郁型
女性
疗效差异
影响因素
焦虑
modified Chaihu Plus Longgu Muli Decoction
insomnia
liver-depression type
female
difference in therapeutic efficacy
influence factors
anxiety
