摘要
伴随身体不适常有体温升高现象,便捷实时体温监测需求剧增。本研究以异丙基丙烯酰胺(NIPAM)、十二烷基硫酸钠(SDS)、N,N'-亚甲基双丙烯酰胺(MBA)、过硫酸铵(APS)为原料,乳液聚合法制备体温敏感型PNIPAM高分子。通过调控SDS添加量,得到不同LCST的PNIPAM。当SDS为0.05g时,PNIPAM在37℃具良好温敏性。以2-甲基丙烯酰氧基乙基磷酰胆碱(MPC)、甲基丙烯酸丁酯(BMA)、对苯乙烯基硼酸(VPBA)为原料,制备水溶性PMBV高分子材料,PMBV与聚乙烯醇(PVA)水中可自发交联成凝胶。将PNIPAM加入PVA混合PMBV水溶液得到复合型温敏水凝胶:高于LCST时呈白色,低于LCST时呈透明状。制备的复合水凝胶具有良好生物相容性且具备高于体温显色特性,可制备可视化温敏变色贴,对体温升高者具有实时提示作用,具有安全、便捷、灵敏性等特点。
Because physical discomfort is frequently linked to high body temperatures,there is a growing need for easy real-time temperature monitoring.The isopropylacrylamide(NIPAM),sodium dodecyl sulfate(SDS),N,N'-methylene bisacrylamide(MBA),and ammonium persulfate(APS)were used to create the temperature-sensitive PNIPAM polymer using emulsion polymerization.By changing the SDS dosage,PNIPAM with various LCSTs was produced.PNIPAM had good temperature sensitivity at 37°C when SDS was 0.05 g.Butyl methacrylate(BMA),2-methylacryloxyethylph osphocholine(MPC),and p-styrylboric acid(VPBA)were used to create the water-soluble PMBV polymer.PMBV and polyvinyl alcohol(PVA)water could be crosslinked to a gel.To create a composite thermosensitive hydrogel that was white when it was higher than LCST and transparent when it was lower than LCST,PNIPAM was added to PVA and combined with PMBV aqueous solution.The created composite hydrogel has good biocompatibility,higher than body temperature color rendering properties,and the ability to create a visual temperature-sensitive color-changing patch with a real-time temperature warning effect.This patch also possesses safety,convenience,and sensitivity qualities.
作者
黄紫璇
黄玘琛
陈子敬
李杨波
杨潇
牟鸣薇
Huang Zixuan;Huang Qichen;Chen Zijing;Li Yangbo;Yang Xiao;Mu Mingwei(School of Food Science and Bioengineering,Changsha University of Science&Technology,Hu'nan,410114)
出处
《当代化工研究》
CAS
2023年第18期43-45,共3页
Modern Chemical Research
基金
湖南省自然科学基金“食品智能储存中两亲性高分子水凝胶的可控制备及调控机理研究”(项目编号:2021JJ40568)
湖南省大学生创新训练项目“温度敏感变色水凝胶的研发与应用”(项目编号:S2021105360024)。
关键词
温度敏感
NIPAM
温敏机理
生物材料
temperature-sensitive
NIPAM
temperature-sensitive mechanism
biomaterials
