摘要
肾纤维化是绝大多数肾脏疾病的共同病理表现。炎症微环境的形成在肾纤维化进程中发挥重要作用。针对炎症尤其是早期炎症的干预措施对临床上防治肾纤维化具有重要意义。羟苯磺酸钙作为一种已确定的血管保护药物,具有抗炎、抗氧化应激的特性,有保护内皮细胞、改善微循环的作用。临床上,羟苯磺酸钙主要用于治疗糖尿病视网膜病变并取得良好的疗效。近年来,有关羟苯磺酸钙的应用及研究逐渐拓展到糖尿病肾脏疾病、梗阻性肾病等肾纤维化疾病。本文就羟苯磺酸钙治疗肾纤维化的研究进展进行综述。
Renal fibrosis is a common pathological manifestation of most renal diseases.Forma-tion of inflammatory microenvironment plays an important role in the progression of renal fibrosis.Inter-vention measures for early inflammation are vital for proper clinical managements of renal fibrosis.With anti-inflammatory and anti-oxidative stress properties,calcium dobesilate is a proven vasoprotective drug of protecting endothelial cells and improving microcirculation.It is mainly indicated for diabetic retinopa-thy.In recent years,the application of calcium dobesilate has been gradually expanded to managing diabet-ic nephropathy and obstructive nephropathy.This review summarized the latest researches of calcium dobesilate in the treatment of renal fibrosis.
作者
何石养
李均
He Shi-yang;Li Jun(Fifth Affiliated(Zhuhai)Hospital,Zunyi Medical University,Zhuhai 519100,China;Zunyi Medical University,Zunyi 563000,China)
出处
《临床肾脏病杂志》
2023年第9期774-778,共5页
Journal Of Clinical Nephrology
基金
国家自然科学基金(81660746)。
关键词
羟苯磺酸钙
肾纤维化
炎症微环境
血管内皮生长因子
核因子ΚB
Calcium dobesilate
Renal fibrosis
Inflammatory microenvironment
Vascular endothelial growth factor
Nuclear factor kappa-B
