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不同剂量芬太尼复合丙泊酚麻醉对经阴道超声引导下无痛取卵术患者妊娠结局影响 被引量:5

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摘要 目的探讨不同剂量芬太尼复合丙泊酚麻醉对经阴道超声引导下无痛取卵术患者妊娠结局的影响。方法选取自2019年1月至2021年1月广西壮族自治区生殖医院收治的192例行经阴道超声引导下无痛取卵术患者为研究对象。根据芬太尼使用剂量将患者分为低剂量组、中剂量组和高剂量组,每组各64例。低剂量组、中剂量组、高剂量组分别给予0.1μg/kg、0.2μg/kg、0.3μg/kg芬太尼复合2.0 mg/kg丙泊酚麻醉。记录并比较3组研究对象的手术指标、麻醉指标、丙泊酚水平、受孕情况及妊娠结局,以及不良反应发生情况。结果3组研究对象的手术时间、出血量及取卵数比较,差异均无统计学意义(P>0.05)。高剂量组的警觉/镇静观察评分低于中剂量组、低剂量组,且中剂量组低于低剂量组,组间比较,差异均有统计学意义(P<0.05)。低剂量组的丙泊酚用量、卵泡液丙泊酚浓度高于中剂量组、高剂量组,且中剂量组均高于高剂量组,组间比较,差异均有统计学意义(P<0.05);低剂量组的血浆丙泊酚浓度高于中剂量组,组间比较,差异均有统计学意义(P<0.05)。3组受精卵率、卵裂率、优质胚胎率、临床妊娠率及活产率比较,差异均无统计学意义(P>0.05)。3组麻醉不良反应发生率比较,差异无统计学意义(P>0.05)。结论对经阴道超声引导下无痛取卵术患者给予高剂量芬太尼复合丙泊酚麻醉,可提高麻醉深度,降低丙泊酚用量及卵泡液丙泊酚浓度,但芬太尼剂量对受孕情况、妊娠结局的影响较小。
出处 《临床军医杂志》 CAS 2023年第7期728-730,共3页 Clinical Journal of Medical Officers
基金 广西壮族自治区卫生健康委员会自筹科研课题(Z20201134)。
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