摘要
目的:分析益气养阴消癥汤辅助治疗晚期食管鳞状细胞癌患者的效果。方法:选择2020年12月-2022年10月梅州市中医医院收治的60例晚期食管鳞状细胞癌患者。采用随机摸红蓝球方式分为常规组(摸蓝球),试验组(摸红球),各30例。常规组采用同步化疗联合特瑞普利单抗治疗,试验组在对照组基础上加用益气养阴消癥汤。比较两组不良反应发生率、治疗效果及治疗前后生活质量评分、血清肿瘤标志物水平。结果:试验组不良反应发生率为13.33%,低于常规组的20.00%,但两组间比较,差异无统计学意义(P>0.05)。试验组总有效率为93.33%,高于常规组的70.00%,差异有统计学意义(P<0.05)。治疗3个月后,两组躯体功能、躯体疼痛、社会功能及总健康状况评分均高于治疗前,且试验组上述各项评分均高于常规组,差异有统计学意义(P<0.05)。治疗3个月后,两组糖类抗原125及癌胚抗原水平均低于治疗前,且试验组均低于常规组,差异有统计学意义(P<0.05)。结论:益气养阴消癥汤辅助治疗晚期食管鳞状细胞癌患者效果更好,能够降低血清肿瘤标志物水平,提高生活质量,同时不良反应较少,安全性良好。
Objective:The effect of Yiqi Yangyin Xiaozheng Decoction in the auxiliary treatment for patients with advanced esophageal squamous cell carcinoma.Method:A total of 60 patients with advanced esophageal squamous cell carcinoma treated in Meizhou Hospital of Traditional Chinese Medicine from December 2020 to October 2022 were selected.According to the random way of touching red and blue balls,they were divided into conventional group(touching blue balls)and experimental group(touching red balls),with 30 cases in each group.The conventional group was treated with synchronous chemotherapy combined with Toripalimab,and the experimental group was treated with Yiqi Yangyin Xiaozheng Decoction on the basis of the control group.The incidence of adverse reactions,therapeutic effect,quality of life score and serum tumor markers before and after treatment were compared between the two groups.Result:The incidence of adverse reactions in the experimental group was 13.33%,which was lower than 20.00%in the conventional group,but there was no significant difference between the two groups(P>0.05).The total effective rate of the experimental group was 93.33%,which was higher than 70.00%of the conventional group,and the difference was statistically significant(P<0.05).After 3 months of treatment,the scores of physical function,physical pain,social function and total health status of both groups were higher than those before treatment,and the scores of the experimental group were higher than those of the conventional group,the differences were statistically significant(P<0.05).After 3 months of treatment,the levels of carbohydrate antigen 125 and carcinoembryonic antigen in two groups were lower than those before treatment,and the levels in the experimental group were lower than those in the conventional group,the differences were statistically significant(P<0.05).Conclusion:Yiqi Yangyin Xiaozheng Decoction has a better effect in the auxiliary treatment of advanced esophageal squamous cell carcinoma patients,it can reduce the level of serum tumor markers,improve quality of life,and have fewer adverse reactions,with good safety.
作者
李剑明
丘昶儒
曾天宝
高志清
LI Jianming;QIU Changru;ZENG Tianbao;GAO Zhiqing(Meizhou Hospital of Traditional Chinese Medicine,Meizhou 514031,China;不详)
出处
《中外医学研究》
2023年第22期5-8,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
梅州市科技计划项目(2020B069)。
关键词
食管鳞状细胞癌
紫杉醇
特瑞普利单抗
益气养阴消癥汤
化疗
Esophageal squamous cell carcinoma
Paclitaxel
Toripalimab
Yiqi Yangyin Xiaozheng Decoction
Chemotherapy
