摘要
Epigenetic reprogramming provides valuable resources for customized pluripotent stem cells generation,which are thought to be important bases of future regenerative medicine.Here we review the commonly used methods for epigenetic reprogramming:somatic cell nuclear transfer,cell fusion,cell extract treatment,inducing pluripotency by defined molecules,and briefly discuss their advantages and limitations.Finally we propose that mechanisms underlying epigenetic reprogramming and safety evaluation platform will be future research directions.
基金
This study was supported by grants from the National Natural Science Foundation of China(Grant Nos.30525040 and 30670229).
