摘要
原发性肝癌是我国最常见的恶性肿瘤之一,介入治疗覆盖中国肝癌分期Ⅰa~Ⅲb期的患者。自噬作为真核细胞特有的代谢过程,参与代谢性疾病、恶性肿瘤的发生、发展,在肝癌的发生、发展中发挥重要作用,尤其促进了肿瘤细胞对介入治疗的耐受,使得治疗效果不佳。本文综述了原发性肝癌常见介入治疗方式对肿瘤细胞自噬现象的影响:消融治疗、经血管介入治疗及内放射治疗都会通过缺氧诱导因子1α(hypoxia inducible factor-1α,HIF-1α)/B淋巴细胞瘤2/腺病毒E1B相互作用蛋白3(B-cell lymphoma-2/adenovirus E1B 19-kDa-interacting protein 3,BNIP3)通路、磷脂酰肌醇3激酶(phosphoinositide 3-kinase,PI3K)/蛋白激酶B(protein kinase B,AKT)/哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)等细胞通路诱导肿瘤细胞自噬水平的提高,从而产生治疗抵抗。体外试验中,自噬抑制剂的使用可以改善自噬引起的治疗抵抗。
Primary hepatic carcinoma is one of most common malignant tumors in China.Interventional therapy plays an important role in primary hepatic carcinoma,suitable for Ia-IIIb stage patients according to China liver cancer staging(CNLC).As a metabolic process unique to eukaryotic cells,autophagy is involved in metabolic diseases and malignant tumors,and plays an important role in the tumorigenesis of primary hepatic carcinoma,especially promoting the tolerance of tumor cells to interventional therapy,which makes the treatment ineffective.In this paper,we review the effects of common interventional treatments for primary hepatic carcinoma on autophagy in tumor cells.Ablation therapy,transvascular interventional therapy,and internal radiation therapy can promote levels of autophagy in tumor cells by cellular pathways such as hypoxia inducible factor-1α(HIF-1α)/B-cell lymphoma-2/adenovirus E1B 19-kDa-interacting protein 3(BNIP3)pathway,phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR),resulting in treatment resistance.In vitro studies,the use of autophagy inhibitors has prevent therapeutic resistance from autophagy.
作者
余晨曦
姚雪松
Yu Chenxi;Yao Xuesong(Department of Interventional Therapy,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Shenzhen 518116,Guangzhou,China;Department of Interventional Therapy,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)
出处
《肝癌电子杂志》
2023年第2期33-36,共4页
Electronic Journal of Liver Tumor
基金
深圳市科技计划(JCYJ20210324125609026)。
关键词
自噬
原发性肝癌
介入治疗
Autophagy
Primary hepatic carcinoma
Interventional therapy
