摘要
目的:探讨结直肠癌组织微卫星不稳定(MSI)状态与病理特征的关系。方法:纳入江西省中西医结合医院2017年1月-2022年1月收治的结直肠癌患者89例开展回顾性研究,经多重荧光聚合酶链式反应(PCR)法对结直肠癌组织的微卫星状态进行检测,记录MSI、微卫星稳定(MSS)状态的检出情况,分析MSI与患者病理特征的关系。结果:在89例患者中,错配修复(MMR)蛋白表达缺失率为38.20%(34/89),未缺失率为61.80%(55/89),MSI占比为39.33%(35/89),MSS占比为60.67%(54/89),患者微卫星状态与MMR蛋白表达有相关性(P<0.05)。患者MSI与年龄、肿瘤部位、分化程度、肿瘤最大径、癌结节、淋巴结转移、远处转移相关(P<0.05)。结论:结直肠癌患者MSI除与年龄有关外,还具备独特的病理特征,以右半结肠、中低分化、肿块大及无癌结节、无淋巴结转移、无远处转移的患者居多,能为该病评估提供参考。
Objective:To investigate the relationship between microsatellite instability(MSI)status and pathological features in colorectal cancer tissues.Method:A retrospective study was carried out on 89 patients with colorectal cancer admitted to Jiangxi Provincial Hospital of Integrated Traditional Chinese and Western Medicine from January 2017 to January 2022.The microsatellite status of colorectal cancer tissue was detected by multiplex fluorescence polymerase chain reaction(PCR)method,the detection of MSI and microsatellite stable(MSS)status was detected,and the relationship between MSI and pathological characteristics of patients was analyzed.Result:Among 89 patients,MMR protein expression deletion rate was 38.20%(34/89),non-deletion rate was 61.80%(55/89),MSI accounted for 39.33%(35/89),and MSS accounted for 60.67%(54/89),Microsatellite status was correlated with the expression of MMR protein(P<0.05).MSI was correlated with age,tumor location,degree of differentiation,maximum tumor diameter,cancer nodules,lymph node metastasis and distant metastasis(P<0.05).Conclusion:MSI in colorectal cancer patients is not only related to age,but also has unique pathological characteristics,such as right colon,medium and low differentiation,large mass,no cancer nodules,no lymph node metastasis,no most patients with distant metastasis can provide reference for the evaluation of the disease.
作者
陈敏洋
CHEN Minyang(Jiangxi Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Nanchang 330003,China)
出处
《中国医学创新》
CAS
2023年第17期136-140,共5页
Medical Innovation of China
关键词
结直肠癌
微卫星不稳定状态
病理特征
多重荧光聚合酶链式反应
Colorectal cancer
Microsatellite instability
Pathological features
Multiplex fluorescence polymerase chain reaction
