摘要
目的:挖掘新型冠状病毒感染的传统中医药防治用药规律。方法:检索中国知网2019年12月1日—2022年12月10日收录的新型冠状病毒感染疫情下的中医方药。利用Excel 2019、IBMSPSS Modeler18.0等软件对中药进行纳入,并且将其使用频数、性味和归经进行汇总统计、关联规则分析。结果:纳入608篇文献,共计151个内服中药复方,依据频次划分,频数为12次以上的有10个复方,按频次由高到低,前5个复方分别为麻杏石甘汤、清肺排毒汤、达原饮、香砂六君子、三仁汤。共涉及187味中药,使用总频次30以上的中药共计35味,以频次由高到低,前5位分别为甘草、茯苓、藿香、苦杏仁、麻黄。中药属性以性寒、温凉为主,味苦、甘、辛多见,归属肺、胃、脾经。将药物进行关联规则分析,前6组关联药物分别为“防风-甘草”“甘草-茯苓”“防风-茯苓”“防风-茯苓-甘草”“防风-半夏”“防风-黄芩”。45对复方药物的关联组合中,共涉及到20味中药,分别为杏仁、麻黄、石膏、防风、甘草、黄芩、连翘、陈皮、苍术、茯苓、半夏、生姜、霍香、白术、麦冬、厚朴、桂枝、桔梗、柴胡、人参,组合为麻杏石甘汤加减。结论:相关文献数据显示,中医药方法治疗新型冠状病毒感染要以辛凉宣泄、清肺平喘止咳为主,麻杏石甘汤为基础方,又根据疾病发展的阶段以及感受病邪的不同,方药也有所不同,比如预防期时,患者当以益气固表为主,加以黄芪、防风益气固表,又因新型冠状病毒发展初期,主要是感染寒湿之气,可适当配伍一些散寒祛湿化痰的药,不仅如此,新型冠状病毒易损伤胃脾,故可加入茯苓、苍术健脾祛湿。总之,通过对中医药治疗新型冠状病毒感染经验规律的迅速总结,将其转化为重要的临床证据,为今后新型冠状病毒疫情提供更好的疗效。
Objective:To explore the TCM medicine prevention and treatment of new coronary pneumonia and the medication rule.Methods:We searched CNKI from December 1,2019 to December 10,2022 of TCM medicine in the prevention and treatment of corona virus disease 2019(COVID-19)pneumonia.Using EXCEL2019,IBMSPSS 18.0 Modeler and other software,we can sum up the frequency of use,the nature and flavor or meridian tropism,and analyze the association rules.Results:A total of 608 articles were included,including 151 oral TCM compound prescriptions,10 prescriptions with more than 12 frequency,the frequency of the first 5 compound:the Maxing Shigan decoction(麻杏石甘汤),the Qingfei Paidu decoction(清肺排毒汤),Dayuan Yin(达原饮),the Xiangsha Liujunzi decoction(香砂六君子汤),the Sanren decoction(三仁汤),involving 187 kinds of TCM medicine.A total of 35 kinds of TCM medicines were used less than 30 times.The Top 5 medicine were Gancao(Radix Glycyrrhizae),Fuling(Poria),Huoxiang(Agastache rugosus),Kuxingren(Bitter almond),Mahuang(Ephedra),respectively.TCM medicine attributes to cold,warm and cool-based,and bitter,sweet,pungent natures are more common,the lungs,stomach,spleen meridians are mostly found.The association rules analysis produced Fangfeng(Radix Saposhnikoviae)-Gancao,Gancao-Fuling,Fangfeng-Fuling,Fangfeng-Fuling-Gancao,Fangfeng-Banxia(Rhizoma Pinelliae),Fangfeng-Huangqin(Radix Scutellariae)and other related drug combinations.The 45 combinations of TCM medicines involved 20 TCM medicines,the names are Xingren(Semen Armeniacae Amarum),Mahuang,Shigao(Gypsum Fibrosum),Fangfeng,Gancao,Huangqin,Lianqiao(Fructus Forsythiae),Chenpi(Pericarpium Citri Reticulatae),Cangzhu(Rhizoma Atractylodis),Fuling,Banxia,Shengjiang(Rhizoma Zingiberis Recens),Huoxiang,Baizhu(Rhizoma Atractylodis Macrocephalae),Maidong(Radix Ophiopogonis),Houpo(Cortex Magnoliae Officinalis),Guizhi(Ramulus Cinnamomi),Jiegeng(Radix Platycodonis),Chaihu(Radix Bupleuri),Renshen(Radix Ginseng),the combination is the Maxing Shigan decoction.Conclusion:The related literature data shows that the TCM medicine method to treat the new coronavirus pneumonia should mainly be the clearing heat with pungent and catharsis to clear lung,relieve asthma and cough,the Maxing Shigan decoction is as its basic prescription,and according to the stage of disease development and feel the invasion of the different pathogenic factors,prescriptions are also different,for example,when the prevention period,patients should be mainly treated by Qi(气)-reinforcing method plus Huangqi(Radix Astragali),Fangfeng,in the early stage of the development of COVID-19,COVID-19 mainly infects cold and dampness,so it can be combined with some medicines to dispel cold and dampness,and dissipate phlegm.In a word,the rapid summarization of the rule of experience in treating COVID-19 in TCM will be transformed into important clinical evidence,which will provide better curative effect for COVID-19 epidemic in the future.
出处
《中医临床研究》
2023年第14期29-35,共7页
Clinical Journal Of Chinese Medicine
