摘要
目的分析胰腺神经内分泌肿瘤患者术后的预后影响因素并建立列线图预测模型。方法收集SEER数据库2010—2014年接受手术治疗的791例胰腺神经内分泌肿瘤患者的临床病理资料。采用Kaplan-Meier法分析不同临床病理特征对患者预后的影响,采用多因素Cox生存分析胰腺神经内分泌肿瘤患者术后的独立预后影响因素并建立列线图预测模型。结果Kaplan-Meier法显示性别、年龄、种族、M分期、组织学分级、淋巴结组清扫数目与患者预后均有关(均P<0.05);多因素Cox生存分析显示年龄、M分期、组织学分级、淋巴结组清扫数目均是胰腺神经内分泌肿瘤患者术后的独立预后影响因素(均P<0.05),并基于上述指标建立列线图预后模型。结论年龄、M分期、组织学分级、淋巴结组清扫数目是胰腺神经内分泌肿瘤患者术后的独立预后影响因素,基于上述指标建立预后预测模型可较准确地预测预后。
Objective To investigate the prognostic factors of pancreatic neuroendocrine neoplasms patients and to construct a prognosis predicting model.Methods Clinical data of 791 patients with pancreatic neuroendocrine neoplasms who underwent surgical resection from 2010 to 2014 were obtained from the SEER database.The factors affecting patient prognosis were analyzed by Kaplan-Meier method and Cox multivariate survival analysis;and a nomogram prediction model was developed on the basis of the factors affecting prognosis.Results Kaplan-Meier analysis showed that gender,age,race,M stage,histological grade,and number of lymph node dissections were correlated with patient prognosis(all P<0.05).Cox multivariate analysis showed that age,M stage,histological grade,and number of lymph node dissections were independent prognostic indicators for patients with pancreatic neuroendocrine neoplasms(all P<0.05),and a nomogram prognostic model was established based on the above indicators.Conclusion Age,M stage,histological grade,and number of lymph node dissections are independent prognostic factors for patients with pancreatic neuroendocrine neoplasms;and a prognostic nomogram based on these indicators has been developed in the study.
作者
祝君
沈红波
ZHU Jun;SHEN Hongbo(Department of Gastroenterology,Quzhou People's Hospital(Quzhou Affiliated Hospital of Wenzhou Medical University),Quzhou 324000,China;不详)
出处
《浙江医学》
CAS
2023年第12期1279-1282,共4页
Zhejiang Medical Journal
关键词
胰腺神经内分泌肿瘤
预后因素
列线图
Pancreatic neuroendocrine neoplasms
Prognostic factors
Nomogram
