摘要
目的:基于数据挖掘分析和总结曹建雄教授治疗原发性支气管肺癌的遣方用药规律,为中医药防治本病提供参考依据。方法:收集整理曹建雄教授2020年9月—2021年9月治疗原发性支气管肺癌的初诊病案,通过中医传承辅助平台(V2.5),使用关联规则、频数及聚类分析等技术对病案中的处方进行归纳分析。结果:本研究共收集原发性支气管肺癌病案203例,有效处方203个,涉及212味中药,使用频次居前10位的分别是陈皮、全蝎、柴胡、法半夏、枳壳、甘草、太子参、浙贝母、防风、海螵蛸;四气以温、寒性多见;五味以苦、甘为主;药物多入肺、脾、肝经;通过关联规则分析得到108种药物组合,其中2味中药组合77组、3味中药组合29组、4味中药组合2组;基于无监督熵层次聚类挖掘出16个核心组合与8个新处方。结论:曹建雄教授治疗原发性支气管肺癌初期以清肺化痰、降逆止咳、软坚散结为主,晚期注重补益气血、养阴生津,各个阶段均重视顾护脾胃,肺脾同治,体现出组方用药源于严谨的临床辨证,充分发挥了中医药的独特优势。
Objective:To analyze and summarize Professor CAO Jianxiong’s prescription for treating primary bronchogenic carcinoma based on data mining,and to providea reference for TCM prevention and treatment of this disease.Methods:The medical records of Professor CAO Jianxiong for the treatment of primary bronchial lung cancer from September 2020 to September 2021 were collected,and the prescriptions in the medical records were summarized and analyzed using association rules,frequency and cluster analysis techniques through the Traditional Chinese Medicine Inheritance assistance platform(V2.5).Results:A total of 203 cases of primary bronchial lung cancer were collected in this study,and 203 effective prescriptions were included,involving 212 TCM medicine.The top 10 frequently used TCM medicine were Chenpi(Citri Reticulatae Pericarpium),Quanxie(scorpion),Chaihu(Bupleurum chinense),Fabanxia(Rhizoma Pinelliae),Zhike(Fructus Aurantii),Gancao(Radix Glycyrrhizae),Taizishen(Radix Pesudostellariae),Zhebiemu(Fritillaria thunbergii),Fangfeng(Radix Saposhnikoviae Divaricatae),and Haipiaoxiao(Sepiae Endoconcha).In four Qi(气),warm and iced are more common.In five tastes,bitter and sweet are mainly.Drugs were into the lung,spleen,liver meridian.A total of 108 drug combinations were obtained by association rule analysis,including 77 groups of 2 kinds of TCM combinations,29 groups of 3 kinds of TCM combinations and 2 groups of 4 kinds of TCM combinations.Sixteen core combinations and eight new prescriptions were mined based on unsupervised entropy hierarchical clustering.Conclusion:Professor CAO Jianxiong’s treatment of lung cancer in the early stage was mainly giving clearing lung and dissolving phlegm,reducing the reverse and relieving cough,and resolving nodulation medication.In late stage,treatment should be focus on supplementing Qi and blood,nourishing Yin(阴)and promoting fluid.At each stage,attention was paid to the care of spleen and stomach and the simultaneous treatment of lung and spleen,which reflected that prescription and medicine originated from rigorous clinical syndrome differentiation and gave full play to the unique advantages of TCM medicine.
出处
《中医临床研究》
2023年第10期40-47,共8页
Clinical Journal Of Chinese Medicine
基金
湖南省重点研发计划项目(2018SK2127)
湖南省中医药科研计划项目(201946)。
关键词
原发性支气管肺癌
数据挖掘
用药规律
Primary bronchogenic carcinoma
Data mining
Medication rule
