摘要
目的探讨氨甲环酸联合卡前列素氨丁三醇预防瘢痕子宫产妇产后出血的效果。方法选取2020年7月至2021年7月我院收治的66例瘢痕子宫产妇为研究对象,采用随机数字表法将其分为观察组(n=33,术后给予氨甲环酸+卡前列素氨丁三醇治疗)和对照组(n=33,术后给予卡前列素氨丁三醇治疗)。比较两组的出血量、产后出血发生率、血常规指标、血压、心率、凝血功能指标及产后并发症发生情况。结果观察组的术后2 h内及术后2~24 h出血量均少于对照组,差异具有统计学意义(P<0.05)。术后24 h,观察组的血红蛋白(Hb)水平及红细胞压积(HCT)均明显高于对照组,差异具有统计学意义(P<0.05)。术后24 h,观察组的收缩压、舒张压高于对照组,心率低于对照组,差异具有统计学意义(P<0.05)。术后24 h,观察组的凝血酶原时间(PT)及活化部分凝血活酶时间(APTT)短于对照组,纤维蛋白原(Fbg)水平高于对照组(P<0.05)。结论氨甲环酸联合卡前列素氨丁三醇可更有效地预防瘢痕子宫产妇产后出血情况,保持其血常规指标、血压及心率正常,改善凝血功能,值得推广。
Objective To investigate the effect of tranexamic acid combined with carboprost tromethamine on prevention of postpartum hemorrhage in parturients with scar uterus.Methods A total of 66 pregnant women with scar uterus admitted in our hospital from July 2020 to July 2021 were selected as the research objects.The pregnant women were divided into observation group(n=33,given tranexamic acid+carboprost tromethamine treatment after operation)and control group(n=33,given carboprost tromethamine treatment after operation)by random number table method.The amount of bleeding,the incidence of postpartum hemorrhage,blood routine indexes,blood pressure,heart rate,coagulation function indexes and postpartum complications were compared between the two groups.Results The amount of bleeding at 2 h and 2-24 h after operation in the observation group was less than that in the control group,and the difference was statistically significant(P<0.05).At 24 h after operation,the hemoglobin(Hb)level and hematocrit(HCT)in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).At 24 h after operation,the systolic blood pressure and diastolic blood pressure in the observation group were higher than those in the control group,the heart rate was lower than that in the control group,and the differences were statistically significant(P<0.05).At 24 h after operation,the prothrombin time(PT)and activated partial thromboplastin time(APTT)in the observation group were shorter than those in the control group,the fibrinogen(Fbg)level was higher than that in the control group(P<0.05).Conclusion Tranexamic acid combined with carboprost tromethamine can more effectively prevent postpartum hemorrhage in parturients with scar uterus,maintain normal blood routine indexes,blood pressure and heart rate,and improve coagulation function,which is worthy of promotion.
作者
李淑馨
马耀芳
LI Shuxin;MA Yaofang(Gynecology and Obstetrics Department,Yulin No.2 Hospital,Yulin 719000,China)
出处
《临床医学研究与实践》
2023年第18期69-72,共4页
Clinical Research and Practice
关键词
氨甲环酸
卡前列素氨丁三醇
瘢痕子宫
产后出血
tranexamic acid
carboprost tromethamine
scar uterus
postpartum hemorrhage
