摘要
目的:观察中西医结合治疗重症肺炎(severe pneumonia,SP)致呼吸衰竭(respiratory failure,RF)的临床疗效。方法:将86例SP致RF患者按照随机数字表法分为对照组和观察组,每组各43例。对照组给予常规西医治疗,观察组在对照组治疗的基础上给予清肺化痰汤。比较两组患者的临床疗效、不良反应发生率及治疗前后中医证候积分、血气指标[动脉血氧分压(arterial oxygen partial pressure,PaO_(2))和动脉二氧化碳分压(arterial partial pressure of carbon dioxide,PaCO_(2))]、炎性因子水平[超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、白细胞介素-6(interleukin-6,IL-6)及肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]变化情况。结果:两组患者治疗后PaO_(2)高于本组治疗前、PaCO_(2)水平低于本组治疗前,治疗后组间比较,差异具有统计学意义(P<0.05)。两组患者治疗后hs-CRP、IL-6和TNF-α水平低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后中医证候积分低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。观察组有效率高于对照组,差异具有统计学意义(P<0.05)。观察组不良反应发生率低于对照组,差异无统计学意义(P<0.05)。结论:中西医结合治疗SP致RF,可改善患者肺通气功能,减轻炎症反应,提高临床疗效,且安全性较好。
Objective:To observe the clinical efficacy ofintegrated traditional Chinese and Western medicine therapy on respiratory failure(RF)caused by severe pneumonia.Methods:A total of 86 RF patients induced by SP were randomly divided into the control group and the observation group according to random number table method,with 43 cases in each group.The control group received routine Western medicine treatment,while the observation group received Lung-Clearing and Phlegm-Resolving Decoction on the basis of the control group's treatment.The clinical eficacy,incidence of adverse reactions,changes of TCM syndrome scores,blood gas indexes[including arterial oxygen partial pressure(PaO_(2))and arterial partial pressure of carbon dioxide(PacO_(2))],inflammatory factor levels[including hypersensitive C-reactive protein(hs CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)J were compared.Results:After treatment,the PaO,levels of the two groups of patients were higher than those of the same group before treatment,while the PaCO_(2)levels were lower than those of the same group before treatment,and all the dfferences between the two groups were statistically significant(P<0.05);The levels of hs-CRP,IL-6,and TNF-αwere lower than those of the same group before treatment,and the observation group's above levels were lower than those of the control group,and all the dfferences between the two groups were statistically significant(P<0.05);The TCM syndrome scores of the two groups were lower than those of the same group before treatment,and the observation group's were lower than those of the control group,and all the differences between the two groups were statistically significant(P<0.05).The effective rate of the observation group was higher than that of the control group,and the difference was statistically sig-nificant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was not statistically significant(P<0.05).Conclusion:Integrated traditional Chinese and Western medicine therapy for RF induced by SP can improve the patient's lung ventilation function,reduce inflammatory reactions,improve clinical efficacy,and have good safety.
作者
张海锋
ZHANG Haifeng(Zhengzhou Yangcheng Hospital,Dengfeng,Henan,China,452470)
出处
《河南中医》
2023年第7期1072-1076,共5页
Henan Traditional Chinese Medicine
关键词
重症肺炎
呼吸衰竭
清肺化痰汤
中西医结合疗法
severe pneumonia(SP)
respiratory failure(RF)
Lung-Clearing and Phlegm-Resolving Decoction
integrated traditional Chinese and Western medicine therapy
