摘要
目的探讨极低出生体重儿(very low birth weight infant,VLBWI)发生早产儿视网膜病(retinopathy of prematurity,ROP)的危险因素。方法回顾性选取甘肃省妇幼保健院新生儿科2020年10月至2021年12月收治的胎龄≤32周VLBWI为研究对象,根据是否发生ROP分为ROP组和非ROP组。比较两组患儿的临床资料,分析VLBWI发生ROP的危险因素。结果共251例VLBWI纳入研究,包括ROP组60例(23.9%)和非ROP组191例(76.1%)。ROP组胎龄、出生体重小于非ROP组[28(26,30)周比29(28,31)周、1035(840,1285)g比1260(1110,1380)g],氧疗时间、输血次数、高血糖发生率、第1周平均血糖值、第1周血糖峰值大于非ROP组[42.0(26.0,53.5)d比24.0(18.0,34.0)d、2.5(1.0,3.0)次比2.0(1.0,2.0)次、80.0%比16.8%、(5.6±0.5)mmol/L比(5.1±0.5)mmol/L、10.4(7.8,13.2)mmol/L比6.5(6.1,6.8)mmol/L],差异均有统计学意义(P<0.001)。多因素回归分析显示,氧疗时间长(OR=1.047,95%CI 1.008~1.087,P=0.018)和第1周血糖峰值高(OR=1.268,95%CI 1.092~1.474,P=0.002)是VLBWI发生ROP的独立危险因素。结论第1周血糖峰值高和氧疗时间长是VLBWI发生ROP的危险因素。
Objective To study the risk factors for retinopathy of prematurity(ROP)in very low birth weight infants(VLBWIs).Methods From October 2020 to December 2021,VLBWIs with gestational age(GA)≤32 weeks admitted to the neonatal department of our hospital were retrospectively studied.According to the occurrence of ROP,they were assigned into ROP group and non-ROP group.The clinical data of the two groups were compared and the risk factors of ROP in VLBWI were analyzed.Results A total of 251 VLBWIs were enrolled,including 60 cases(23.9%)in ROP group and 191(76.1%)in non-ROP group.The GA and birth weight(BW)of ROP group were significantly lower than non-ROP group[28(26,30)w vs.29(28,31)w,1035(840,1285)g vs.1260(1110,1380)g,respectively,all P<0.001].The ROP group had longer duration of oxygen therapy[42.0(26.0,53.5)d vs.24.0(18.0,34.0)d],higher incidences of blood transfusion[2.5(1.0,3.0)times vs.2.0(1.0,2.0)times]and hyperglycemia(80.0%vs.16.8%),higher average[(5.6±0.5)mmol/L vs.(5.1±0.5)mmol/L]and peak[10.4(7.8,13.2)mmol/L vs.6.5(6.1,6.8)mmol/L]blood glucose levels in the first week than the non-ROP group(all P<0.001).Multivariate analysis showed that longer duration of oxygen therapy(OR=1.047,95%CI 1.008-1.087,P=0.018)and higher peak blood glucose level in the first week(OR=1.268,95%CI 1.092-1.474,P=0.002)were the independent risk factors for ROP.Conclusions Longer duration of oxygen therapy and higher peak of blood glucose level in the first week are risk factors for ROP in VLBWIs.
作者
陈冠初
杨婷
唐建明
谈笑
易彬
高红霞
Chen Guanchu;Yang Ting;Tang Jianming;Tan Xiao;Yi Bin;Gao Hongxia(Department of Neonatology,Gansu Provincial Women and Child-care Hospital,Gansu Provincial Pediatric Medical Center,Gansu Central Hospital,Lanzhou 730050,China)
出处
《中华新生儿科杂志（中英文）》
CAS
CSCD
2023年第6期349-353,共5页
Chinese Journal of Neonatology
基金
甘肃省儿科临床医学研究中心项目(18JR2FA004)
甘肃省卫生行业科研计划项目(GSWSKY-2019-13)
甘肃省卫生行业科研计划项目(GSWSKY-2019-17)。
关键词
高血糖
早产儿视网膜病
极低出生体重儿
早产儿
Hyperglycemia
Retinopathy of prematurity
Very low birth weight infant
Premature infant
