摘要
目的 观察百合地黄汤联合团体认知行为疗法(group-cognitive behavioral therapy-insomnia,G-CBT-I)对老年失眠患者的疗效。方法 选取老年失眠患者120例,随机分为中药组及联合组各60例,中药组予百合地黄汤加味治疗,联合组予百合地黄汤加味联合G-CBT-I治疗,2个组患者均连续治疗8周,通过失眠严重程度指数(insomnia severity index, ISI)、匹兹堡睡眠质量指数(pittsburgh sleep quality index,PSQI)量表评估2个组被试在治疗前后及3个月随访时主观睡眠评价、入睡时间等因子分及总分变化情况,根据PSQI减分率评估疗效,不良反应症状量表(treatment emergent symptom scale,TESS)评估不良反应发生情况。结果 治疗结束时联合组总有效率为91.67%,高于中药组(P<0.05);2个组与治疗前比较,治疗后及随访时PSQI、ISI量表总分均下降,PSQI量表中睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、日间功能因子分均有改善(P<0.05);联合组PSQI、ISI量表总分及睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、日间功能等因子分改善优于中药组(P<0.05),且可保持3个月。结论 百合地黄汤联合G-CBT-I在改善老年患者睡眠质量、睡眠效率及日间功能等方面效果显著,疗效优于单独使用百合地黄汤。
Objective To observe the clinical efficacy of Modified Baihe Dihuang Decoction combined with group-cognitive behavioral therapy-insomnia in the treatment of senile insomnia.Methods A total of 120 aging patients with insomnia were selected and randomly divided into traditional Chinese medicine group and combined group,with 60 cases in each group.The traditional Chinese medicine group was treated with Modified Baihe Dihuang decoction,and the combined group was treated with Modified Baihe Dihuang decoction combined with group-cognitive behavioral therapy-insomnia.Both groups were continuously treated for 8 weeks.The changes of subjective sleep evaluation,sleep time and other factor scores and total scores of the two groups before and after treatment and follow-up after 3 months were evaluated by Insomnia severity index(ISI)and Pittsburgh sleep quality index(PSQI).The efficacy was evaluated by the score reduction rate of PSQI.Treatment emergent symptom scale(TESS)was used to evaluate the occurrence of adverse reactions.Results At the end of treatment,the total efficiency of the combined group was 91.67%,higher than that of the traditional Chinese medicine group(P<0.05).Compared with pre-treatment,the total scores of PSQI and ISI scales decreased after treatment and at follow-up,and the factor scores of sleep quality,enter sleep time,sleep duration,sleep efficiency,sleep disorder,and daytime function all improved in the PSQI scale in both groups(P<0.05).Total scores of PSQI,ISI scale and the factor scores of sleep quality,enter sleep time,sleep duration,sleep efficiency,sleep disorder and daytime function of the combined group were better than those of the traditional Chinese medicine group,and could last for 3 months.Conclusion The combination of the Modified Baihe Dihuang decoction and group-cognitive behavioral therapy-insomnia had a significant effect on improving sleep quality,sleep efficiency and daytime function of aging patients.The efficacy was better than Modified Baihe Dihuang decoction alone.
作者
孙旭海
曹峰祥
赵峥峥
杜渐
SUN Xuhai;CAO Fengxiang;ZHAO Zhengzheng;DU Jian(Beijing Xicheng District Desheng Community Health Service Center,Beijing 110120,China;Beijing Zhongyan Chinese Medicine Hospital,Beijing 102401,China;Institute of Basic Research of Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2023年第6期972-975,共4页
JOURNAL OF BASIC CHINESE MEDICINE
基金
中国中医科学院科技创新工程项目(CI2021A00705-1)
北京市自然科学基金青年项目(7204334)。
关键词
百合地黄汤
团体认知行为治疗
老年失眠
临床研究
Baihe Dihuang decoction
Group cognitive behavioral therapy
Senile insomnia
Clinical research
