摘要
Advanced antibacterial technologies are needed to counter the rapid emergence of drug-resistant bacteria.Imageguided therapy is one of the most promising strategies for efficiently and accurately curing bacterial infections.Herein,a chemiluminescence(CL)-dynamic/guided antibacteria(CDGA)with multiple reactive oxygen species(ROS)generation capacity and chemiexcited near-infrared emission has been designed for the precise theranostics of bacterial infection by employing near-infrared emissive carbon nanodots(CDs)and peroxalate as CL fuels.Mechanistically,hydrogen peroxide generated in the bacterial microenvironment can trigger the chemically initiated electron exchange between CDs and energy-riched intermediate originated from the oxidized peroxalate,enabling bacterial induced inflammation imaging.Meanwhile,type Ⅰ/Ⅱ photochemical ROS production and type Ⅲ ultrafast charge transfer from CDs under the self-illumination can inhibit the bacteria proliferation efficiently.The potential clinical utility of CDGA is further demonstrated in bacteria infected mice trauma model.The self-illuminating CDGA exhibits an excellent in vivo imaging quality in early detecting wound infections and internal inflammation caused by bacteria,and further are proven as efficient broad-spectrum antibacterial nanomedicines without drug-resistance,whose sterilizing rate is up to 99.99%.
基金
the support of the National Natural Science Foundation of China(U2004168,12074348 and 11974317)
the Natural Science Foundation of Henan Province(212300410078).
