摘要
目的采用Meta分析的方法对硅类污染物与食管癌发病率之间的关系进行系统评价。方法在Pubmed、Cochrane Library、Embase、万方数据库和中国期刊全文数据库(CNKI)这5个大型数据库中检索有关硅类污染物及食管癌相关的文献,检索到的文献由两位独立的研究者根据纳入、排除标准进行筛选整理后,采用Review Manager 5.3软件进行统计分析。结果共纳入了8篇文献,通过综合统计分析得出总体人群在硅类污染物的暴露下食管癌的发病率高于非暴露组(OR=1.58,95%CI:1.32~1.91,P<0.05)。按性别进行分组后,男性在硅类污染物的暴露下食管癌的发病率仍高于对照组(OR=1.39,95%CI:1.09~1.78,P<0.05)。结论硅类污染物有一定的致癌作用,是食管癌的危险因素,尤其在男性中作用显著。
Objective To evaluate the relationship systematically between silicon pollutants and the incidence of esophageal cancer with Meta-analysis.Methods Literatures related to silicon pollutants and esophageal cancer were searched in Pubmed,Cochrane Library,Embase,Wanfang Database and CNKI.The retrieved literatures were screened and sorted by 2 independent researchers according to inclusion and exclusion criteria,and then reviewed by Review Manager 5.3 software for statistical analysis.Results 8 articles were included.Through comprehensive statistical analysis,the incidence rate of esophageal cancer in the general population exposed to silicon pollutants was higher than that in the non exposed group(OR=1.58,95%CI 1.32~1.91,P<0.05).After grouping by sex,the incidence rate of esophageal cancer in men exposed to silicon pollutants was still higher than that in the control group(OR=1.39,95%CI 1.09~1.78,P<0.05).Conclusion Silicon pollutants have certain carcinogenic effects and are risk factors for esophageal cancer,especially in men.
作者
王俊博
孔德九
范嘉豪
赵迪
王新帅
WANG Jun-bo;KONG De-jiu;FAN Jia-hao;ZHAO Di;WANG Xin-shuai(The First Affiliated Hospital,and College of Clinical Medicine of Henan University of Science and Technology,Luoyang,China,471003)
出处
《食管疾病》
2023年第2期122-126,共5页
Journal of Esophageal Diseases
关键词
食管癌
硅类污染物
META分析
发病率
esophageal cancer
silicon pollutants
Meta-analysis
incidence
