摘要
缺血性脑卒中(IS)是导致全球人类死亡和残疾的主要原因之一。虽然支架植入、脑血管搭桥、溶栓等再灌注治疗技术可使IS患者的缺血部位实现再灌注,但因再灌注治疗引起的脑缺血再灌注损伤(CIRI)却成为了当前临床的治疗难题。目前临床中改善CIRI的诊疗手段有限且常常不能获得满意的疗效,因此,基于分子水平探究CIRI的病理生理机制,以寻求有效的治疗CIRI方法成为了当前的研究焦点。已有研究证实,环状RNA(circRNA)参与了CIRI过程中的许多生理病理过程,充当重要的调节因子,有望成为治疗CIRI的潜在靶点。本文围绕CIRI中circRNA对不同脑细胞的调控作用进行综述,以期为治疗和改善CIRI提供新的潜在靶点。
Ischemic stroke(IS)is one of the main causes of human death and disability all over the world.Although reperfusion treatments,such as stent implantation,cerebrovascular bypass and thrombolysis,can achieve reperfusion in ischemic regions of IS patients,cerebral ischemia-reperfusion injury(CIRI)caused by reperfusion treatment has become a difficult clinical treatment problem.At present,the clinical diagnosis and treatment methods to improve CIRI are limited and often can not obtain satisfactory effect;therefore,CIRI exploration based on molecular level to find an effective method for CIRI has become the focus of current research.Studies have confirmed that circular RNA(circRNA)participates in many physiological/pathological processes in brain CIRI and acts as an important regulator,which is expected to become a potential target for CIRI treatment.This paper focuses on the regulation of circRNA in different cerebral cellular neurons to provide new potential target for CIRI treatment and improvement.
作者
周宇
李斌
马勇
柴尔青
Zhou Yu;Li Bin;Ma Yong;Chai Erqing(First Clinical Medical College,Lanzhou University,Lanzhou 730000,China;Cerebrovascular Disease Center,Gansu Provincial People's Hospital,Lanzhou 730000,China;Key Laboratory of Cerebrovascular Diseases,Lanzhou 730000,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2023年第5期523-528,共6页
Chinese Journal of Neuromedicine
基金
甘肃省自然科学基金 (20JR10RA379)。
