摘要
目的:探究膀胱癌(bladder cancer)组织中脂肪酸结合蛋白6(fatty acid-binding protein6,FABP6)、核苷酸还原酶M1亚基(ribonucleotide reductase regulatory subunit M1,RRM1)的表达水平及其与膀胱癌患者临床病理特征的相关性。方法:回顾性分析2020年2月-2021年12月大冶市人民医院收治的并接受手术切除的40例膀胱癌患者的临床资料。采用免疫组化法检测各组织中的FABP6和RRM1蛋白表达水平,并分析FABP6和RRM1蛋白与各项临床特征的关系。结果:膀胱癌组织中FABP6和RRM1高蛋白表达水平占比均高于癌旁正常组织(P<0.05)。FABP6和RRM1蛋白高表达和低表达膀胱癌患者的性别、年龄、肿瘤类型、肿瘤直径比较,差异均无统计学意义(P>0.05)。FABP6和RRM1蛋白高表达和低表达膀胱癌患者的分化程度、TNM分期、淋巴结转移比较,差异均有统计学意义(P<0.05)。结论:FABP6、RRM1在膀胱癌组织中表达水平高于癌旁正常组织,且两者均参与了膀胱癌的发生、发展进程。
Objective:To investigate the expression levels of fatty acid-binding protein 6(FABP6)and ribonucleotide reductase regulatory subunit M1(RRM1)in bladder cancer tissues,correlation of the two indicators with clinicopathological characteristics of bladder cancer patients.Method:The clinical data of 40 patients with bladder cancer who received surgical resection in Daye People's Hospital from February 2020 to December 2021 were retrospectively analyzed.The protein expression levels of FABP6 and RRM1 in each tissue were detected by immunohistochemical method,and the relationship between FABP6 and RRM1 and various clinical features were analyzed.Result:FABP6 and RRM1 high protein expression levels in bladder cancer tissues were higher than those in adjacent normal tissues(P<0.05).There were no significant differences in gender,age,tumor type or tumor diameter in bladder cancer patients with high and low FABP6 and RRM1 expression(P>0.05).There were significant differences in the degree of differentiation,TNM stage and lymph node metastasis in bladder cancer patients with high and low expression of FABP6 and RRM1 protein(P<0.05).Conclusion:The expression levels of FABP6 and RRM1 in bladder cancer tissues are higher than those in adjacent normal tissues,and both of them were involved in the occurrence and development of bladder cancer.
作者
王莉莉
WANG Lili(Daye People's Hospital,Hubei Province,Daye 435100,China)
出处
《中国医学创新》
CAS
2023年第13期152-155,共4页
Medical Innovation of China
关键词
膀胱癌
脂肪酸结合蛋白6
核苷酸还原酶M1亚基
临床病理特征
Bladder cancer
Fatty acid binding protein 6
Ribonucleotide reductase regulatory subunit
M1
Clinicopathological features
