摘要
KLF9是锌指蛋白Krüppel样转录因子(Krüppel-like factors,KLFs)家族的重要成员,通过C端的3个C2H2锌指蛋白结构,结合到靶基因启动子区富含GC的区域,调节靶基因的转录,从而参与调节细胞增殖、分化、凋亡和组织器官发育等多个生理过程。本文详细梳理了KLF9在机体代谢、氧化应激、肿瘤的发生发展等多个病理/生理过程中的作用,对近年来发表的KLF9相关文献做一简要概述,为深入解析KLF9的生理功能及其作用机制提供参考。
As a member of the Krüppel-like factors(KLFs)transcription factor family,KLF9 regulates the transcriptions of target genes by 3 C2H2 zinc finger motifs,binding to the GC rich region of the target promoters.KLF9 plays important roles in a variety of biological and cellular processes,including cell proliferation,differentiation,apoptosis,and development of tissues and organs.This review summarizes the roles of KLF9 in diverse pathological/physiological processes,including metabolism,oxidative stress and tumorigenesis.Collectively,this review provides a reference for in-depth analysis of the physiological functions and the underlying mechanisms of KLF9.
作者
卢光振
任文琦
张龙玉
崔安芳
LU Guang-Zhen;REN Wen-Qi;ZHANG Long-Yu;CUI An-Fang(College of Clinical Medicine,Jining Medical University,Jining 272067,China;College of Basic Medicine,Jining Medical University,Jining 272067,China)
出处
《生命科学》
CSCD
北大核心
2023年第4期493-499,共7页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(82000761)。
